EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD

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HASHEMI A.A.S.; MANOCHEHRI NAIENI M.A.; ESLAMI ZIA; LOTFI M.H.; KHEYR ANDISH MARYAM; RAFIEIAN MAHDI

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2009 | Volume:16 | Issue:5 (68) Page(s): 56-60

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Title

EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD

Author(s)

Keywords

FLOWCYTOMETRYQ3

CD MARKERQ3

ACUTE LYMPHOBLASTIC LEUKEMIAQ3

IMMUNOPHENOTYPEQ2

Abstract

Introduction: IMMUNOPHENOTYPE is an important factor for determining the mode of treatment in ACUTE LYMPHOBLASTIC LEUKEMIA. The aim of this study was to determine distribution rate of ALL phenotypes by FLOWCYTOMETRY. Methods: This observational study was conducted by a case series method. The study population included children (0-1467) with ALL admitted to Shahid Sadoughi hospital.In order to determine the CD MARKERs, bone marrow aspiration samples of 56 patient were sent to the FLOWCYTOMETRY center of Yazd Blood Transfusion Center. According to the percentage of CD MARKERs , the groups and subgroup of leukemic cells were determined and the relation between prognostic factors with the type of leukemic cells (T- cell, B-cell) was analyzed by using statistical tests.Results: According to FLOWCYTOMETRY results, 31 patient (59.6%) had T-cell IMMUNOPHENOTYPE and 21 patient (40.4%) had B-cell IMMUNOPHENOTYPE. In this study, although the frequency of undesirable prognostic factors in T-cell group was more than B-cell ALL, the difference was significant only for the male patients (p: 0.02).Conclusion: Prevalence of T- cell in our population is greater than other parts of the world that may be due to environmental factors including carcinogenic agents. There was no significant difference between the out come of the two group (B-cell and T-cell), which can be due to the selection of the type of chemical therapy based on risk factors.

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References

BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY

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APA: Copy

HASHEMI, A.A.S., MANOCHEHRI NAIENI, M.A., ESLAMI, ZIA, LOTFI, M.H., KHEYR ANDISH, MARYAM, & RAFIEIAN, MAHDI. (2009). EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 16(5 (68)), 56-60. SID. https://sid.ir/paper/35697/en

Vancouver: Copy

HASHEMI A.A.S., MANOCHEHRI NAIENI M.A., ESLAMI ZIA, LOTFI M.H., KHEYR ANDISH MARYAM, RAFIEIAN MAHDI. EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;16(5 (68)):56-60. Available from: https://sid.ir/paper/35697/en

IEEE: Copy

A.A.S. HASHEMI, M.A. MANOCHEHRI NAIENI, ZIA ESLAMI, M.H. LOTFI, MARYAM KHEYR ANDISH, and MAHDI RAFIEIAN, “EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 5 (68), pp. 56–60, 2009, [Online]. Available: https://sid.ir/paper/35697/en

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