APPLICATION OF IN VIVO MAGNETIC RESONANCE SPECTROSCOPY FOR MEASURING HUMAN BRAIN METABOLITES

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FAEGHI F.; OGHABIAN M.A.; HASHEMI H.; SIGAROODI H.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2000 | Volume:8 | Issue:2 Page(s): 83-92

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Title

APPLICATION OF IN VIVO MAGNETIC RESONANCE SPECTROSCOPY FOR MEASURING HUMAN BRAIN METABOLITES

Author(s)

FAEGHI F. | OGHABIAN M.A. | HASHEMI H. | SIGAROODI H. | Issue Writer Certificate

Keywords

IN VIVO MAGNETIC RESONANCE SPECTROSCOPYQ4

BRAIN METABOLITESQ4

BRAIN DISEASEQ4

Abstract

In vivo proton Magnetic Resonance Spectroscopy (H-MRS) is one of the noninvasive techniques for measuring important BRAIN METABOLITES. In many cases, MRS may lead to a specific diagnosis when CT and MRI imaging findings are not specific. Furthermore, MRS can detect abnormalities in metabolism even when structures appear normal on CT and MRI. The concentration of important human BRAIN METABOLITES in the white and gray matter of different human cerebral lobes in a group of normal volunteers, including 165 individuals were measured using in vivo H-MRS. At the third stage, the 165 normal volunteers underwent routine MRI study and after inspecting the images, 12 predefined areas of white (8 area) and gray matter (4 area) using the H-MRS technique. Thereafter, the spectrum was obtained and related peak areas were measured using spectral processing software. At this phase, the area data from each metabolite were put into corresponding mathematical equations obtained from the study of the calibration solutions, and the exact concentration of each metabolite (NA, Cr, Cho, Lactate) of each brain area was measured. In this way, the pattern of metabolite distribution in the white and gray matters of different human cerebral lobes was obtained. Statistical tests show that NA concentration (Which is an important neuron marker) in the white matter is significantly higher than in gray matter (P=0.05), and a gradual increase in NA concentration is seen from the frontal to occipital lobes. Creatine has been distributed uniformly in the different cerebral lobes and there was no significant difference seen in its concentration in the white matter of the cerebral lobes (P=0.05). There was also no significant difference in choline concentrations in human brain lobes. Na is significantly lower in gray matter than in white matter (P=0.05), Creatine concentration in gray matter is significantly higher than white matter (P=0.05) but choline concentration in this lobe is significantly lower than white matter (P=0.05). Understanding the concentrations of important BRAIN METABOLITES and their pattern of distribution in different human cerebral lobes may be useful as an index for primary differential noninvasive diagnosis of human BRAIN DISEASEs.

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APA: Copy

FAEGHI, F., OGHABIAN, M.A., HASHEMI, H., & SIGAROODI, H.. (2000). APPLICATION OF IN VIVO MAGNETIC RESONANCE SPECTROSCOPY FOR MEASURING HUMAN BRAIN METABOLITES. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 8(2), 83-92. SID. https://sid.ir/paper/35761/en

Vancouver: Copy

FAEGHI F., OGHABIAN M.A., HASHEMI H., SIGAROODI H.. APPLICATION OF IN VIVO MAGNETIC RESONANCE SPECTROSCOPY FOR MEASURING HUMAN BRAIN METABOLITES. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;8(2):83-92. Available from: https://sid.ir/paper/35761/en

IEEE: Copy

F. FAEGHI, M.A. OGHABIAN, H. HASHEMI, and H. SIGAROODI, “APPLICATION OF IN VIVO MAGNETIC RESONANCE SPECTROSCOPY FOR MEASURING HUMAN BRAIN METABOLITES,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 2, pp. 83–92, 2000, [Online]. Available: https://sid.ir/paper/35761/en

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