Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAKERI MARYAM; FATEMI IMAN; Zakeri Mohammad Ali; ALLAHTAVAKOLI MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:26 | Issue:10 Page(s): 910-920

Download Full-Text

Persian Verion

View:

442

Download:

Cites:

Information Journal Paper

Title

Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice

Author(s)

ZAKERI MARYAM | FATEMI IMAN | Zakeri Mohammad Ali | ALLAHTAVAKOLI MOHAMMAD | Issue Writer Certificate

Keywords

AgingQ2

MetforminQ2

OvariectomyQ2

Muscle strengthQ2

MemoryQ2

AnxietyQ2

Abstract

Introduction: Aging process is inevitable, which increases the risk of illness and death in people. Menopause occurs as a part of the Aging process. The aim of this study was to evaluate the effect of Metformin (Met) on Muscle strength, Anxiety and Memory in ovariectomized mice Methods: Thiswas an experimental study. 96 female mice (Age 6 months) (20-25 g) were randomly divided into sex groups, including: (1) sham, (2) ovariectomized, (3 and 4) ovariectomized + Met (1 and 10 mg/kg) (5) Met 10 mg/kg, and (6) healthy. At first, the mice were ovariectomized and then received Met for six months. Muscle strength, Memory, and Anxiety in the exprimental groups was examined. Statistical analysis was performed via SPSS16 and the differences between groups were analyzed by one way ANOVA. Results: The results of the study showed Met with doses of 1 mg / kg and 10 mg significantly reduced the Anxiety of mice (p = 0. 0295 and p = 0. 0024, respectively), increased Memory (p = 0. 0004 and p = 0. 0044, respectively) and at dose of 10 mg / kg it improved Muscle strength (p = 0. 0148) compared to the Ovariectomy group. Conclusion: Metformin has beneficial effects on behavioural manifestations of Aging and ovarectomy.

Cites

No record.

References

No record.

Cite

APA: Copy

ZAKERI, MARYAM, FATEMI, IMAN, Zakeri, Mohammad Ali, & ALLAHTAVAKOLI, MOHAMMAD. (2019). Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(10 ), 910-920. SID. https://sid.ir/paper/35852/en

Vancouver: Copy

ZAKERI MARYAM, FATEMI IMAN, Zakeri Mohammad Ali, ALLAHTAVAKOLI MOHAMMAD. Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(10 ):910-920. Available from: https://sid.ir/paper/35852/en

IEEE: Copy

MARYAM ZAKERI, IMAN FATEMI, Mohammad Ali Zakeri, and MOHAMMAD ALLAHTAVAKOLI, “Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 10 , pp. 910–920, 2019, [Online]. Available: https://sid.ir/paper/35852/en

Related Journal Papers