EFFECT OF GLYCYRRHIZA GLABRA AND VITAMIN C ON ACRYLAMIDE-INDUCED MOTOR DYSFUNCTION

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MIRJALILI A.; DASHTI RAHMATABADI M.H.; REZVANI M.E.; TALEBI A.R.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2014 | Volume:22 | Issue:5 Page(s): 1567-1576

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Title

EFFECT OF GLYCYRRHIZA GLABRA AND VITAMIN C ON ACRYLAMIDE-INDUCED MOTOR DYSFUNCTION

Author(s)

MIRJALILI A. | DASHTI RAHMATABADI M.H. | REZVANI M.E. | TALEBI A.R. | Issue Writer Certificate

Keywords

ACRYL AMIDEQ2

GLYCYRRHIZA GLABRAQ2

OPEN FIELD TESTQ2

RATQ3

VITAMIN CQ2

WEIGHTQ2

Abstract

Introduction: Acrylamide is a chemical compound which can be produced while frying carbohydrates in high- temperatures. Since the neurotoxicity of acrylamide was reported in the previous studies, the aim of the present study was to investigate the effects of co-administration of GLYCYRRHIZA GLABRA and VITAMIN C on acrylamide-induced WEIGHT loss and motor deficits in RATs. Methods: In this experimental study, 40 Wistar male RATs aged 28 days were divided in to five groups of 8 RATs including Control, Acrylamide, Acrylamide + VITAMIN C, Acrylamide + GLYCYRRHIZA GLABRA and Acrylamide +Vitamin C + GLYCYRRHIZA GLABRA. All treatments were administered for 6 weeks. Thereafter, locomotor activity indices were measured using open field apparatus. In order to analyze the study data, One-way ANOVA followed by Tukey's test was used. Results: The results showed that motor activity was significantly increased in VITAMIN C + GLYCYRRHIZA GLABRA group compared with ACRYL AMIDE group. While treatment with VITAMIN C or GLYCYRRHIZA GLABRA alone did not cause any significant changes in locomotor activity indices. In addition, RATs treated with the combination of VITAMIN C and GLYCYRRHIZA GLABRA significantly improved WEIGHT gain deficiency induced by Acrylamide. Conclusion: The study findings revealed that the co-administration of VITAMIN C and GLYCYRRHIZA GLABRA can retard the locomotor dysfunction and improve the WEIGHT gain in acrylamide-treated RATs.

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APA: Copy

MIRJALILI, A., DASHTI RAHMATABADI, M.H., REZVANI, M.E., & TALEBI, A.R.. (2014). EFFECT OF GLYCYRRHIZA GLABRA AND VITAMIN C ON ACRYLAMIDE-INDUCED MOTOR DYSFUNCTION. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 22(5), 1567-1576. SID. https://sid.ir/paper/35899/en

Vancouver: Copy

MIRJALILI A., DASHTI RAHMATABADI M.H., REZVANI M.E., TALEBI A.R.. EFFECT OF GLYCYRRHIZA GLABRA AND VITAMIN C ON ACRYLAMIDE-INDUCED MOTOR DYSFUNCTION. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(5):1567-1576. Available from: https://sid.ir/paper/35899/en

IEEE: Copy

A. MIRJALILI, M.H. DASHTI RAHMATABADI, M.E. REZVANI, and A.R. TALEBI, “EFFECT OF GLYCYRRHIZA GLABRA AND VITAMIN C ON ACRYLAMIDE-INDUCED MOTOR DYSFUNCTION,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 1567–1576, 2014, [Online]. Available: https://sid.ir/paper/35899/en

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