THE EFFECT OF SYNBIOTIC GAZ FORTIFIED WITH BETA-CAROTENE CONSUMPTION ON GLYCEMIC CONTROL AND BLOOD LIPIDS OF PATIENTS WITH TYPE 2 DIABETES

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SAYYEDI F.; ASEMI Z.; GOLI M.; BAHMANI F.; ALIZADEH S.; ESMAILLZADEH A.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2016 | Volume:11 | Issue:1 Page(s): 1-10

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Title

THE EFFECT OF SYNBIOTIC GAZ FORTIFIED WITH BETA-CAROTENE CONSUMPTION ON GLYCEMIC CONTROL AND BLOOD LIPIDS OF PATIENTS WITH TYPE 2 DIABETES

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Keywords

SYNBIOTICQ1

INSULIN RESISTANCEQ2

GLYCEMIC CONTROLQ2

BLOOD LIPIDQ2

TYPE 2 DIABETESQ3

Abstract

Background & Objectives: Recent evidence suggests that antioxidants and SYNBIOTICs intake due to the effect on inflammatory cytokines and oxidative stress may affect the GLYCEMIC CONTROL and BLOOD LIPIDs of diabetic patients. The aim of study was to investigate the effect of SYNBIOTIC Gaz fortified with beta-carotene consumption on metabolic profile among patients with TYPE 2 DIABETES (T2D).Materials and Methods: This randomized double-blinded cross-over controlled clinical trial was conducted among 51 patients with T2D aged 35-70 y. After a 2-wk run-in period, the individuals were randomly assigned to consume either a SYNBIOTIC Gaz fortified with beta-carotene (n=51) or control food (n=51) for 6 weeks. A 3-week washout period was applied; then the subjects were crossed over to the alternate treatment arm for an additional 6 weeks. The SYNBIOTIC Gaz fortified with beta-carotene contained a probiotic viable and heat-resistance strain Lactobacillus sporogenes (1×107 CFU), 0.15 g inulin as prebiotic and 0.04 g betacarotene. The control food (the same substance without probiotic bacteria, prebiotic inulin and beta-carotene) was packed in identical 7-gram packages. The patients were asked to consume the SYNBIOTIC or control Gaz three times a day. Fasting blood samples were taken at baseline and after 6-wk phase of intervention to measure the metabolic profile.Results: After 6 weeks of intervention, SYNBIOTIC Gaz fortified with beta-carotene consumption compared with the control Gaz has resulted in a significant decrease in serum insulin (changes from baseline: -1.00±7.90 vs. +3.68±6.91 mIU/mL, P=0.002), HOMA-IR (-0.73±3.96 vs. +1.82±4.09, P=0.002), HOMA-B (-0.52±19.75 vs. +8.71±17.15, P=0.01), triglycerides (-2.86±49.53 vs. +20.14±50.10 mg/dL, P=0.02), VLDL-cholesterol (-0.57±9.90 vs. +4.03±10.02 mg/dL, P=0.02) and total-/HDL-cholesterol ratio (-0.01±1.08 vs. +0.64±0.81, P=0.001).Conclusion: In conclusion, consumption of the SYNBIOTIC Gaz fortified with beta-carotene for 6 weeks among the T2D patients compared with the control Gaz had beneficial effects on the serum insulin concentrations, INSULIN RESISTANCE, triglycerides, VLDL-cholesterol, and total-/HDL-cholesterol, but not on other biochemical profiles.

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APA: Copy

SAYYEDI, F., ASEMI, Z., GOLI, M., BAHMANI, F., ALIZADEH, S., & ESMAILLZADEH, A.. (2016). THE EFFECT OF SYNBIOTIC GAZ FORTIFIED WITH BETA-CAROTENE CONSUMPTION ON GLYCEMIC CONTROL AND BLOOD LIPIDS OF PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 11(1), 1-10. SID. https://sid.ir/paper/359128/en

Vancouver: Copy

SAYYEDI F., ASEMI Z., GOLI M., BAHMANI F., ALIZADEH S., ESMAILLZADEH A.. THE EFFECT OF SYNBIOTIC GAZ FORTIFIED WITH BETA-CAROTENE CONSUMPTION ON GLYCEMIC CONTROL AND BLOOD LIPIDS OF PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2016;11(1):1-10. Available from: https://sid.ir/paper/359128/en

IEEE: Copy

F. SAYYEDI, Z. ASEMI, M. GOLI, F. BAHMANI, S. ALIZADEH, and A. ESMAILLZADEH, “THE EFFECT OF SYNBIOTIC GAZ FORTIFIED WITH BETA-CAROTENE CONSUMPTION ON GLYCEMIC CONTROL AND BLOOD LIPIDS OF PATIENTS WITH TYPE 2 DIABETES,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 11, no. 1, pp. 1–10, 2016, [Online]. Available: https://sid.ir/paper/359128/en

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