THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS

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HOSEINI RASTEGAR; BABAEI PARVIN; DAMIRCHI ARSALAN

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Journal: Journal of Birjand University of Medical Sciences Year:2016 | Volume:23 | Issue:1 Page(s): 0-0

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Title

THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS

Author(s)

HOSEINI RASTEGAR | BABAEI PARVIN | DAMIRCHI ARSALAN | Issue Writer Certificate

Keywords

VITAMIN D SUPPLEMENTATION

OVARIECTOMIZED

INSULIN RESISTANT

Abstract

Background and Aim: Type 2 diabetes mellitus (T2DM) and vitamin D deficiency are both too common during menopause. Since the effect of different doses of vitamin D supplements on blood sugar, insulin concentration and insulin resistance are unknown, the present study aimed at investigating the effects of different doses of the vitamin D supplements on visceral fat, blood sugar, insulin concentration, and insulin resistance in OVARIECTOMIZED rats.Materials and Methods: In this randomized experimental study, 32 female Wistar rats were divided into 4 equal groups as follows: three groups. that received vitamin D supplements (high, moderate, and low dose) and one control group. After 8 weeks of different doses of VITAMIN D SUPPLEMENTATION plasma concentration of glucose, insulin and HOMA-IR were measured in the three groups. The obtained data was statistically analyzed by means of dependent t-test and ANOVA. at the significance level of P<0.05.Results: After a period of eight-week intervention, body weight, BMI, waist circumference, visceral fat, insulin, blood glucose and HOMA-IR at high, moderate, and low doses of VITAMIN D SUPPLEMENTATION were significantly lower than those in the control group (P<0.05). High dose of vitamin D compared with moderate and low doses significantly caused reduction in insulin, blood glucose, and HOMA-IR (P<0.001 for all three variables).Conclusion: The findings of the current study showed that a high dose of vitamin D causes significant improvements in FPG, insulin, and insulin resistance evaluated by HOMA-IR. It was also found that adding vitamin D supplements can improve glucose control in menopause model of rats.

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APA: Copy

HOSEINI, RASTEGAR, BABAEI, PARVIN, & DAMIRCHI, ARSALAN. (2016). THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 23(1), 0-0. SID. https://sid.ir/paper/359136/en

Vancouver: Copy

HOSEINI RASTEGAR, BABAEI PARVIN, DAMIRCHI ARSALAN. THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(1):0-0. Available from: https://sid.ir/paper/359136/en

IEEE: Copy

RASTEGAR HOSEINI, PARVIN BABAEI, and ARSALAN DAMIRCHI, “THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/359136/en

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