THE EFFECT OF METFORMIN ON TACTILE LEARNING AND ANXIETY LIKE-BEHAVIOR IN OVARIECTOMIZED MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DELROBAEI F.; BAHMANI M.; AYOOBI F.; SHAMSIZADEH A.; FATEMI I.; ALLAHTAVAKOLI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:3 Page(s): 196-205

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

826

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF METFORMIN ON TACTILE LEARNING AND ANXIETY LIKE-BEHAVIOR IN OVARIECTOMIZED MICE

Author(s)

Keywords

OVARIECTOMYQ2

METFORMINQ2

LEARNINGQ2

ANXIETYQ2

Abstract

Introduction: Estrogen regulates many processes in the brain such as synaptic formation, LEARNING, and memory. Empirical evidence shows that there is a correlation among menopause, memory impairment, and ANXIETY due to Estrogen deficiency. In this study, we tested the effect of METFORMIN (Met) with antioxidant effect, which can improve the impairment of tactile LEARNING and ANXIETY-like behavior in ovarectomized mice.Methods: Thirty-two female mice weighting 20±5 g were randomly divided into four groups of eight, including sham group, OVARIECTOMY, OVARIECTOMY with doses 7 and 15 mg/kg of Met. At first, mice were ovariectomized and then they were treated with the doses of the Met or water for 21 days. Then, tactile LEARNING (by Novel Object Recognition Test) and ANXIETY like-behavior (by Elevated Plus-maze) were determined.Results: Met at the doses of 7 or 15 mg/kg significantly improved tactile LEARNING compared to the OVARIECTOMY group. Met at the doses of 7 or 15 mg/kg significantly increased Open Arm Time (%OAT) and Open Arm Entries (%OAE) compared to the OVARIECTOMY group.Conclusion: Met especially at the dose of 7 mg/kg showed a significant role in improving the ANXIETY and tactile LEARNING in the ovariectomized mice.

Cites

No record.

References

Cite

APA: Copy

DELROBAEI, F., BAHMANI, M., AYOOBI, F., SHAMSIZADEH, A., FATEMI, I., & ALLAHTAVAKOLI, M.. (2017). THE EFFECT OF METFORMIN ON TACTILE LEARNING AND ANXIETY LIKE-BEHAVIOR IN OVARIECTOMIZED MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(3), 196-205. SID. https://sid.ir/paper/36038/en

Vancouver: Copy

DELROBAEI F., BAHMANI M., AYOOBI F., SHAMSIZADEH A., FATEMI I., ALLAHTAVAKOLI M.. THE EFFECT OF METFORMIN ON TACTILE LEARNING AND ANXIETY LIKE-BEHAVIOR IN OVARIECTOMIZED MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(3):196-205. Available from: https://sid.ir/paper/36038/en

IEEE: Copy

F. DELROBAEI, M. BAHMANI, F. AYOOBI, A. SHAMSIZADEH, I. FATEMI, and M. ALLAHTAVAKOLI, “THE EFFECT OF METFORMIN ON TACTILE LEARNING AND ANXIETY LIKE-BEHAVIOR IN OVARIECTOMIZED MICE,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3, pp. 196–205, 2017, [Online]. Available: https://sid.ir/paper/36038/en

Related Journal Papers