INVESTIGATING THE KLF4 GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS

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HOSSEINPOUR FEYZI M.; SHIRI TORKAMANI S.; BABAEI E.; GHANBARIAN M.; MONTAZERI V.; HALIMI M.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2014 | Volume:21 | Issue:5 Page(s): 599-608

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Title

INVESTIGATING THE KLF4 GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS

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Keywords

BREAST CANCERQ2

KLF4Q2

ONCOGENEQ2

SEMIQUANTITATIVE RT-PCRQ2

TUMOR SUPPRESSORQ2

Abstract

Introduction: Krupple-like factor4 is a transcription factor which is involved in many cancers including BREAST CANCER. BREAST CANCER is the most common malignancy among women. Due to the high prevalence of these tumors, there are ongoing efforts to find molecular markers which can recognize nontumoral from tumoral tissues. Therefore, the aim of this study was to evaluate the potential usefulness of KLF4 as a potential diagnostic and therapeutic molecular marker in BREAST CANCER.Methods: In the current study, 31 tumoral and 21 non tumoral adjacent tissues were evaluated. Transcription levels were measured by Semiquantitative Reverse Transciptase-Polymerase Chain Reaction and were normalized by the b2m as an endogenous PCR control. Data was analyzed by spss software, one-way ANOVA and T-test.Results: The results showed that: 1) KLF4 is over expressed in Breast tumors rather than adjacent normal tissues. 2) KLF4 is an ONCOGENE in breast tumors (at least in IDC type). 3) The KLF4 expression levels are related significantly with nature of malignant breast tumors.Conclusion: Findings do not confirm KLF4 as a diagnostic marker in classification and identification of tumoral tissues from non-tumoral ones in breast, but we can use this marker to identify at least 50% of invasive Ductal Carcinoma in breast and utilize it as a potential predictive factor to demonstrate severity degree in various tumors.

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APA: Copy

HOSSEINPOUR FEYZI, M., SHIRI TORKAMANI, S., BABAEI, E., GHANBARIAN, M., MONTAZERI, V., & HALIMI, M.. (2014). INVESTIGATING THE KLF4 GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 21(5), 599-608. SID. https://sid.ir/paper/36068/en

Vancouver: Copy

HOSSEINPOUR FEYZI M., SHIRI TORKAMANI S., BABAEI E., GHANBARIAN M., MONTAZERI V., HALIMI M.. INVESTIGATING THE KLF4 GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(5):599-608. Available from: https://sid.ir/paper/36068/en

IEEE: Copy

M. HOSSEINPOUR FEYZI, S. SHIRI TORKAMANI, E. BABAEI, M. GHANBARIAN, V. MONTAZERI, and M. HALIMI, “INVESTIGATING THE KLF4 GENE EXPRESSION AS A NEW MOLECULAR MARKER IN BREAST TUMORS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 5, pp. 599–608, 2014, [Online]. Available: https://sid.ir/paper/36068/en

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