EFFECT OF PRAZOSIN ON MORPHINE WITHDRAWAL SIGNS IN RAT

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BABAII A.; GHAFGHAZI T.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2000 | Volume:8 | Issue:4 Page(s): 63-67

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Title

EFFECT OF PRAZOSIN ON MORPHINE WITHDRAWAL SIGNS IN RAT

Author(s)

BABAII A. | GHAFGHAZI T. | Issue Writer Certificate

Keywords

CLONIDINEQ3

PRAZOSINQ3

MORPHINE WITHDRAWALQ4

JUMPINGQ4

ALPHA-1 ADRENOCEPTORSQ4

Abstract

CLONIDINE an alpha-2 adrenergic agonist besides being used as antihypertensive, also causes analgesia and antagonizes the opiate withdrawal syndrome. CLONIDINE pretreatment in morphine dependent rats reduced the frequency of precipitated shakes but potentiated the frequency of escape attempts during naloxone induced withdrawal. Piloetection and excitement were also potentiated by CLONIDINE pretreatment. The purpose of this study was to ascertain whether or not potentiation of some withdrawal signs by CLONIDINE is mediated by ALPHA-1 ADRENOCEPTORS activation. To produce morphine dependence, morphine hydrochloride was added to drinking water. Morphine solution was prepared each day and the concentration was increased in two days interval. The abstinence syndrome was precipitated by injecting naloxone (3 mg/kg i.p). CLONIDINE and for prasosin were administered i.p. 10 and 20 minutes before naloxone, respectively. Some of withdrawal signs including escape attempts and precipitated shakes were counted during a fifteen minutes period after naloxone. CLONIDINE (0.5 and 1 mg/kg) reduced most of the withdrawal sings, but in a dose dependent manner, the drug potentiates the number of escape attempts that was in agreement with previous studies. In morphine dependent rats, PRAZOSIN pretreatment (0.1 and 0.4 mg/kg) did not affect any of the withdrawal sings except piloerection Co-administration of PRAZOSIN with CLONIDINE in all doses significantly decreased the number of escape attempts in comparison with CLONIDINE pretreated group. Furthermore, PRAZOSIN inhibited piloerection, another sign of withdrawal that was potentiated by CLONIDINE. This study indicates the involvement of ALPHA-1 ADRENOCEPTORS in some of MORPHINE WITHDRAWAL sings and potentiation of these signs during CLONIDINE treatment.

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APA: Copy

BABAII, A., & GHAFGHAZI, T.. (2000). EFFECT OF PRAZOSIN ON MORPHINE WITHDRAWAL SIGNS IN RAT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 8(4), 63-67. SID. https://sid.ir/paper/36110/en

Vancouver: Copy

BABAII A., GHAFGHAZI T.. EFFECT OF PRAZOSIN ON MORPHINE WITHDRAWAL SIGNS IN RAT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;8(4):63-67. Available from: https://sid.ir/paper/36110/en

IEEE: Copy

A. BABAII, and T. GHAFGHAZI, “EFFECT OF PRAZOSIN ON MORPHINE WITHDRAWAL SIGNS IN RAT,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 4, pp. 63–67, 2000, [Online]. Available: https://sid.ir/paper/36110/en

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