In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line

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Pourkamalzadeh M.; ABTAHI FROUSHANI S.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian South Medical Journal Year:2019 | Volume:22 | Issue:5 Page(s): 264-277

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Information Journal Paper

Title

In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line

Author(s)

Pourkamalzadeh M. | ABTAHI FROUSHANI S.M. | Issue Writer Certificate

Keywords

Cell proliferationQ2

iron chelating agentsQ1

gliomaQ2

B92 cellsQ1

Abstract

Background: Research suggests the inhibitory effects of deferoxamine as an iron chelator on erythroleukemia cells. The present study was conducted to investigate the effects of deferoxamine on B92 cells as a model of glial cells carcinoma. Materials and Methods: The present experimental study treated 6×104 B92 cells with 0, 10, 50 and 100 μ M of deferoxamine for 24 hours in the presence or absence of 10 μ mol/l of ferric chloride. Morphological changes were evaluated in the treated cells compared to in the control sample using an inverse optical microscope. The inhibitory and cytotoxic effects of deferoxamine were evaluated using the dimethylimidazole-diphenyl tetrazolium bromide (MTT) reduction and neutral red uptake assay. The data were analyzed using the Kruskal-Wallis test. P <0. 05 was set as the level of statistical significance. Results: The inhibitory effects of deferoxamine on the proliferation of B92 cells were identified after 24 hours in a way that the cells began to accumulate in the presence of deferoxamine. Ten μ mol/l of ferric chloride prevented these morphological changes. Deferoxamine was also found to significantly and dose-dependently inhibit the vitality and viability of B92 cells. Moreover, the data showed that ferric chloride prevents the emergence of the effects of treating B92 cells with deferoxamine. Conclusion: Deferoxamine exerts in-vitro antiproliferative effects on the glial cell line B92.

Cites

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APA: Copy

Pourkamalzadeh, M., & ABTAHI FROUSHANI, S.M.. (2019). In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 22(5 ), 264-277. SID. https://sid.ir/paper/361380/en

Vancouver: Copy

Pourkamalzadeh M., ABTAHI FROUSHANI S.M.. In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2019;22(5 ):264-277. Available from: https://sid.ir/paper/361380/en

IEEE: Copy

M. Pourkamalzadeh, and S.M. ABTAHI FROUSHANI, “In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 22, no. 5 , pp. 264–277, 2019, [Online]. Available: https://sid.ir/paper/361380/en

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