Effect of adding Ketamine to morphine in patient controlled analgesia of patients addicted to opioid with post orthopedic operation pain

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NAJAFI NAJMEH; HOSSEINI HABIBOLLAH; HATAMI MARYAM; VAKILI MAHMOOD; Shishebor Farzaneh; ZAMANIAN MOHAMMAD; HAKIMIZADEH ELHAM

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:3 Page(s): 257-265

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Title

Effect of adding Ketamine to morphine in patient controlled analgesia of patients addicted to opioid with post orthopedic operation pain

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Keywords

Post-operative painQ3

Orthopedic operationQ2

IV patient-controlled analgesiaQ1

MorphineQ2

KetamineQ2

AddictionQ2

Abstract

Introduction: Post-operative pain reduction is one of the problems in the patients with preoperative narcotic dependency. Morphine is the most common drugs to control postoperative pain. Due to resistance to Morphine and its side effects in addict patients, using of adjuvant drugs such as Ketamine has increased. The aim of this study was to evaluate the effect of adding Ketamine to Morphine in patients addicted to opioid with post Orthopedic operation pain. Methods: In a double blind clinical trial, 60 patients undergoing Orthopedic operation with history of opioid consumption were randomly divided in 2 groups. Post operation, the first group received Morphine 20 mg and the second group received Morphine 20 mg + Ketamine 100 mg via IV patient-controlled analgesia (IPCA). The pain score as visual analogue scale (VAS), sedation score, and nausea and vomiting were evaluated at 1, 6, 12 and 24 hours post operation. SPSS v. 20 was used for data analysis. Results: Results showed that dose of Morphine consumption in Morphine group was significantly increased compared to the Morphine + Ketamine group (p ˂ 0. 001). In addition, only at 12 hours after surgery the mean of pain score in the Morphine group was significantly reduced compared to the second group (p = 0. 02). The mean of sedation score at 1 (p ˂ 0. 001), 6 (p = 0. 002), 12 (p = 0. 001) and 24 (p ˂ 0. 001) hours after surgery in the Morphine group was increased compared to the other group. At 1 hour, the mean of nausea and vomiting scores in the Morphine group was significantly reduced compared to the Morphine + Ketamine group (p = 0. 024). Conclusion: Addition of Ketamine to Morphine in the patients with history of opioid consumption reduced using of the Morphine. But had no effect on pain and sedation score reduction.

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APA: Copy

NAJAFI, NAJMEH, HOSSEINI, HABIBOLLAH, HATAMI, MARYAM, VAKILI, MAHMOOD, Shishebor, Farzaneh, ZAMANIAN, MOHAMMAD, & HAKIMIZADEH, ELHAM. (2018). Effect of adding Ketamine to morphine in patient controlled analgesia of patients addicted to opioid with post orthopedic operation pain. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(3 ), 257-265. SID. https://sid.ir/paper/36208/en

Vancouver: Copy

NAJAFI NAJMEH, HOSSEINI HABIBOLLAH, HATAMI MARYAM, VAKILI MAHMOOD, Shishebor Farzaneh, ZAMANIAN MOHAMMAD, HAKIMIZADEH ELHAM. Effect of adding Ketamine to morphine in patient controlled analgesia of patients addicted to opioid with post orthopedic operation pain. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(3 ):257-265. Available from: https://sid.ir/paper/36208/en

IEEE: Copy

NAJMEH NAJAFI, HABIBOLLAH HOSSEINI, MARYAM HATAMI, MAHMOOD VAKILI, Farzaneh Shishebor, MOHAMMAD ZAMANIAN, and ELHAM HAKIMIZADEH, “Effect of adding Ketamine to morphine in patient controlled analgesia of patients addicted to opioid with post orthopedic operation pain,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 3 , pp. 257–265, 2018, [Online]. Available: https://sid.ir/paper/36208/en

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