EFFECTS OF A NEW QUINAZOLINONE COMPOUND ON UNDERLYING IONIC CURRENTS INDUCED IN AN EPILEPTIC MODEL USING VOLTAGE CLAMP TECHNIQUE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JANAHMADI M.; GANJKHANI M.; FATHI MOGHADAM H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2003 | Volume:7 | Issue:4 (30) Page(s): 319-330

Download Full-Text

Persian Verion

View:

1,058

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF A NEW QUINAZOLINONE COMPOUND ON UNDERLYING IONIC CURRENTS INDUCED IN AN EPILEPTIC MODEL USING VOLTAGE CLAMP TECHNIQUE

Author(s)

JANAHMADI M. | GANJKHANI M. | FATHI MOGHADAM H. | Issue Writer Certificate

Keywords

PTZQ3

QUINAZOLINONEQ4

EPILEPSYQ4

VOLTAGE CLAMPQ4

HELIX ASPERSAQ4

Abstract

Background: EPILEPSY is a neurological disorder in which nerve cells of the brain from time to time release abnormal electrical impulses. These cause a temporary malfunction of the never cells of the brain. Materials and methods: In this experimental study, two electrode voltage and current clamp techniques were used to determine the efficacy of a new QUINAZOLINONE compound on PTZ induced epileptiform activity and underlying ionic conductance in D5 neuronal membrane of HELIX ASPERSA. Results: The results demonstrated that the convulsant drug PTZ (25mM) changed the shape and increased the frequency of spontaneous action potentials. At holding potential of - 40 m V, PTZ led to a reduction in amplitude of inward and outward currents. Extracellular application of the new QUINAZOLINONE compound (0.1 mM) in epileptic model produced a hyperpolarization of the resting membrane potential and a decrease in frequency of action potentials. Under VOLTAGE CLAMP condition, tested new compound decreased the peak amplitude of the inward and increased the outward currents. Application of the new compound added PTZ, caused a reduction in frequency, amplitude and duration potential. Resting membrane, potential was affected and shifted towards more hyperpolarized voltage. At holding potential of - 40 m V, the new compound in the absence of PTZ depressed the total membrane conductance. Simultaneous application of QUINAZOLINONE and PTZ produced a remarkable reduction in membrane ionic currents. Conclusion: It may be concluded that new QUINAZOLINONE compound causes a reduction in cellular excitability and inhibition of PTZ induced epileptic activity via changing membrane ionic conductance.

Cites

No record.

References

Cite

APA: Copy

JANAHMADI, M., GANJKHANI, M., & FATHI MOGHADAM, H.. (2003). EFFECTS OF A NEW QUINAZOLINONE COMPOUND ON UNDERLYING IONIC CURRENTS INDUCED IN AN EPILEPTIC MODEL USING VOLTAGE CLAMP TECHNIQUE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 7(4 (30)), 319-330. SID. https://sid.ir/paper/362262/en

Vancouver: Copy

JANAHMADI M., GANJKHANI M., FATHI MOGHADAM H.. EFFECTS OF A NEW QUINAZOLINONE COMPOUND ON UNDERLYING IONIC CURRENTS INDUCED IN AN EPILEPTIC MODEL USING VOLTAGE CLAMP TECHNIQUE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2003;7(4 (30)):319-330. Available from: https://sid.ir/paper/362262/en

IEEE: Copy

M. JANAHMADI, M. GANJKHANI, and H. FATHI MOGHADAM, “EFFECTS OF A NEW QUINAZOLINONE COMPOUND ON UNDERLYING IONIC CURRENTS INDUCED IN AN EPILEPTIC MODEL USING VOLTAGE CLAMP TECHNIQUE,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 7, no. 4 (30), pp. 319–330, 2003, [Online]. Available: https://sid.ir/paper/362262/en

Related Journal Papers