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Information Journal Paper

Title

The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in hippocampus tissue of male wistar rats

Pages

  74-84

Abstract

 Background: Unit of p65 is one of the subunits of NF-κ B and its phosphorylation by Stress oxidative causes activation of NF-κ B. The aim of present study was to investigate the effects of adenosine injection after Brain ischemia reperfusion injury on gene expression of NF-κ B /p65 and Reactive Oxygen Species (ROS) in Hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were randomly divided into four groups, healthy control (n=10), ischemia reperfusion (n=10), ischemia reperfusion + adenosine dose of 0. 1 mg/kg (n=10) and ischemia reperfusion + adenosine dose of 0. 4 mg/kg (n=10). The animals were subjected to ischemia by the ligation of common carotid arteries for 45 min. Intraperitoneal injection of adenosine was done after 24 h ischemia in rats. The gene expression of NF-κ B /P65 and ROS activity were examined by Real time-PCR and Spectroflourimeter, respectively. One-way ANOVA and Bonferroni post hoc test were used to analysis the data. The significant level was set at p<0. 05. Results: The results showed that ischemia induced significant increase in gene expression of NF-κ B /p65 and ROS activity compared to control group (p<0. 05). Also, both dose of adenosine resulted in significant decrease in gene expression of NF-κ B /p65 and ROS activity compared to ischemia group (p<0. 05). Conclusion: Brain ischemia reperfusion causes the Stress oxidative. It appears that injection of adenosine is effective in reduction of Stress oxidative and Inflammation due to Brain ischemia reperfusion.

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    APA: Copy

    Jozaie, Atossa, MOVAHEDI, MONIREH, KHOSRAVI, MARYAM, & GOLAB, FERESHTEH. (2019). The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in hippocampus tissue of male wistar rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(2 ), 74-84. SID. https://sid.ir/paper/362440/en

    Vancouver: Copy

    Jozaie Atossa, MOVAHEDI MONIREH, KHOSRAVI MARYAM, GOLAB FERESHTEH. The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in hippocampus tissue of male wistar rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(2 ):74-84. Available from: https://sid.ir/paper/362440/en

    IEEE: Copy

    Atossa Jozaie, MONIREH MOVAHEDI, MARYAM KHOSRAVI, and FERESHTEH GOLAB, “The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in hippocampus tissue of male wistar rats,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 2 , pp. 74–84, 2019, [Online]. Available: https://sid.ir/paper/362440/en

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