In Vivo Mechanisms of Radioadaptive Response

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Rajabi Pour M.; FARDID R.

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Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:9 | Issue:2 Page(s): 1384-1398

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Information Journal Paper

Title

In Vivo Mechanisms of Radioadaptive Response

Author(s)

Rajabi Pour M. | FARDID R. | Issue Writer Certificate

Keywords

adaptive responseQ1

Low-dose RadiationQ1

Ionizing RadiationQ1

DNA RepairQ1

Bystander effectQ1

CancerQ2

Abstract

Background & Objectives: Radioadaptive response (RAR) describes a phenomenon in which small priming doses of Ionizing Radiation (IR) reduce detrimental effects of subsequent higher doses. Since IR-induced carcinogenesis is a main concern in the Low-dose Radiation risk assessmen, the aim of this study was to investigate the RAR with the end points of carcinogenesis and the related genomic damages and evaluation of the effective in-vivo mechanisms in this phenomenon. Materials & Methods: The present review article was performed by using the research and review articles indexed in Pubmed, Google scholar, Science direct. In this review article, some resent studies related to RAR with end points of carcinogenesis in different species of mice and human lymphocytes has been investigated. Additionally, in the present review article, the role of important in vivo mechanisms involved in adaptive response, namely DNA Repair, Bystander effect and endocrine system hormones such as glucocorticoids has been investigated. Results: These studies, often revealed efficient induction of RAR by chronic or repeated low-dose priming irradiation. Conclusion: Current radiation protection regulations do not include RAR because of the large variability in expression among individuals and uncertainties of the mechanism. However, in the future, RAR should be regarded as an indispensable factor for estimation and control of individual IR sensitivity.

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APA: Copy

Rajabi Pour, M.. (2019). In Vivo Mechanisms of Radioadaptive Response. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 9(2 ), 1384-1398. SID. https://sid.ir/paper/362507/en

Vancouver: Copy

Rajabi Pour M.. In Vivo Mechanisms of Radioadaptive Response. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;9(2 ):1384-1398. Available from: https://sid.ir/paper/362507/en

IEEE: Copy

M. Rajabi Pour, “In Vivo Mechanisms of Radioadaptive Response,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 9, no. 2 , pp. 1384–1398, 2019, [Online]. Available: https://sid.ir/paper/362507/en

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