Antibacterial Effect of New Compounds Against Lactococcus garvieae

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RAHDAR A.; GHASEMI B.; HASHEMI S.H.; Moghaddam Manesh M.R.

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Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:9 | Issue:3 Page(s): 1605-1612

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Information Journal Paper

Title

Antibacterial Effect of New Compounds Against Lactococcus garvieae

Author(s)

RAHDAR A. | GHASEMI B. | HASHEMI S.H. | Moghaddam Manesh M.R. | Issue Writer Certificate

Keywords

Antibacterial EffectQ2

New CompoundsQ1

L.garvieaeQ1

Abstract

Background & Objective: Lactococcus garvieae is one of the most important zoonotic pathogens that threatens the aquaculture industry. The recognition and use of new antibacterial compounds is one the best ways to control this pathogen. In this study, inhibitory effects of Zn nanoparticles, thioethers derivatives, poly-L-lysine, nisin, glycine and hydroalcoholic extracts of Rosemary and Prosopis farcta leaves were assessed against L. garvieae. Materials & Methods: Antibacterial Effect of all compounds were evaluated via the disk diffusion and broth microdilution methods. The results were reported as inhibition zone diameter (IZD), the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC) values. Results: Any significant inhibitory effect was observed on L. garvieae with poly-L-lysine, nisin, glycine and hydroalcoholic extracts of Rosemary. Antibacterial Effectof twothioethers derivatives, Zn nanoparticles and hydroalcoholic extracts of Prosopis farcta leaves was observed with IZD = 9. 48-18. 35 mm, MIC = 32-4096 μ g/ml and MBC = 64-2048 μ g/ml. The best inhibitory effect was belonged to thioethers derivative 4e. Conclusion: Antibacterial Effect of thioethers derivatives, Zn nanoparticles and hydroalcoholic extracts of Prosopis farcta leaves were proven on L. garvieae invitro. New ligands and complexes can be designed according tested thioethers especially derivative 4e in future researches to improve antimicrobial properties.

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