COMPARING HIGH DOSE VITAMIN B6 WITH CORTICOTHERAPY IN INFANTILE SPASM

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JAVADZADEH M.; MOHAVALATI F.; GHOFRANI M.

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Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2004 | Volume:6 | Issue:3 Page(s): 209-270

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Information Journal Paper

Title

COMPARING HIGH DOSE VITAMIN B6 WITH CORTICOTHERAPY IN INFANTILE SPASM

Author(s)

JAVADZADEH M. | MOHAVALATI F. | GHOFRANI M. | Issue Writer Certificate

Keywords

VITAMIN B6 PREDNISOLONEQ3

INFANTILE SPASMQ3

Abstract

Background: Since present available treatments for INFANTILE SPASMs (IS) are far from adequate, and also side effects of the current therapeutic regimens are frequent and serious, the ongoing search for better protocols is understandable. Methods and Materials: We compared the therapeutic and adverse effects of vitamin B6 given in high doses with prednisolone in a randomized controlled double blind clinical trial. Vitamin B6 (40mg/kg/24hr) and prednisolone (1.5mg/kg/day) were tried in 22 and 15 patients respectively, and the patients were followed for at least 6 months. Results: Response to treatment was slightly better in the prednisolone group but the difference was not significant (P=0.4). On the other hand adverse effects were also seen more frequently with prednisolone. Conclusions: We conclude that high dose vitamin B6 should be looked at as a justified and worth-trying method of treatment. It seems that it can be safely used where there is contraindication to use other antiepileptic drugs or where they have failed, and even in fresh cases of IS.

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APA: Copy

JAVADZADEH, M., MOHAVALATI, F., & GHOFRANI, M.. (2004). COMPARING HIGH DOSE VITAMIN B6 WITH CORTICOTHERAPY IN INFANTILE SPASM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 6(3), 209-270. SID. https://sid.ir/paper/363623/en

Vancouver: Copy

JAVADZADEH M., MOHAVALATI F., GHOFRANI M.. COMPARING HIGH DOSE VITAMIN B6 WITH CORTICOTHERAPY IN INFANTILE SPASM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2004;6(3):209-270. Available from: https://sid.ir/paper/363623/en

IEEE: Copy

M. JAVADZADEH, F. MOHAVALATI, and M. GHOFRANI, “COMPARING HIGH DOSE VITAMIN B6 WITH CORTICOTHERAPY IN INFANTILE SPASM,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 6, no. 3, pp. 209–270, 2004, [Online]. Available: https://sid.ir/paper/363623/en

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