Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery

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MASOUDIFAR MEHRDAD; NAZEMROAYA BEHZAD; RAHIMI ZAHRA; KHADEMI MEHDI

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:3 Page(s): 311-318

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Information Journal Paper

Title

Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery

Author(s)

MASOUDIFAR MEHRDAD | NAZEMROAYA BEHZAD | RAHIMI ZAHRA | KHADEMI MEHDI | Issue Writer Certificate

Keywords

MidazolamQ3

DexmedetomidineQ1

Sedation levelQ3

Stereotaxic SurgeryQ1

Abstract

Background and Objective: Sedation in critical surgeries such as brain stereotaxic surgeries is an important issue due to the need for hemodynamic stability of the patients. Midazolam andDexmedetomidine account as important sedative drugs in clinic. Their role as sedatives are well proven in different studies but there no previous study has attempted to compare their influence on hemodynamic and post operation complication in brain Stereotaxic Surgery. Subjects and Methods: In this clinical trial, 64 patients candidate for brain Stereotaxic Surgery went under sedation with Midazolam or Dexmedetomidine and hemodynamic values such as systolic and diastolic blood pressure, heart rate, respiratory rate, Sedation level, patient and surgeon satisfaction, recovery time after surgery and post operation complications were evaluated and collected and data were analyzed. Results: In both groups (Midazolam or Dexmedetomidine) mean systolic and diastolic blood pressure and heart rate had no differences but respiratory rate in Midazolam group was lower than Dexmedetomidine group and they also experienced more frequent apnea episodes and decreased O2 saturation. Conclusion: Dexmedetomidine is safer drug in comparison to Midazolam and use of this drug is suggested in critical surgeries such as brain stereotaxic surgeries in which hemodynamic stabilities are important. Dexmedetomidine causes fewer respiratory complications than Midazolam.

Cites

A comparison of sedation quality with midazolam-ketamine versus propofol-ketamine during Phacoemulsification surgery

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APA: Copy

MASOUDIFAR, MEHRDAD, NAZEMROAYA, BEHZAD, RAHIMI, ZAHRA, & KHADEMI, MEHDI. (2019). Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(3 ), 311-318. SID. https://sid.ir/paper/364084/en

Vancouver: Copy

MASOUDIFAR MEHRDAD, NAZEMROAYA BEHZAD, RAHIMI ZAHRA, KHADEMI MEHDI. Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(3 ):311-318. Available from: https://sid.ir/paper/364084/en

IEEE: Copy

MEHRDAD MASOUDIFAR, BEHZAD NAZEMROAYA, ZAHRA RAHIMI, and MEHDI KHADEMI, “Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 3 , pp. 311–318, 2019, [Online]. Available: https://sid.ir/paper/364084/en

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