HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ALLIUM URSINUM IN DIABETIC RATS

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FALLAHI F.; ROGHANI M.; KHALILZAD M.

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Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2011 | Volume:19 | Issue:1 (76) Page(s): 65-74

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Title

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ALLIUM URSINUM IN DIABETIC RATS

Author(s)

FALLAHI F. | ROGHANI M. | KHALILZAD M. | Issue Writer Certificate

Keywords

ALLIUMQ2

DIABETES MELLITUSQ3

GLUCOSEQ2

LIPIDSQ3

Abstract

Introduction: The hypoglycemic and hypolipidemic effects of ALLIUM ursinum (AU) were investigated in an experimental model of DIABETES MELLITUS, invitro.Methods: Male Wistar rats were divided into control, AU-treated control, diabetic glibenclamide-treated, and AU-treated diabetic groups. For induction of diabetes, streptozocin (STZ) was intraperitoneally administered (60 mg/Kg). AU-treated groups received AU mixed with standard pelleted food at a weight ratio of 1% for 2 months. Serum GLUCOSE and LIPIDS levels were determined before the study and at the 4th and 8th week after the study.Results: Serum GLUCOSE was significantly lower in AU-treated diabetic rats at the end of the 4th and 8th weeks (p<0.005 and p<0.01 respectively) as compared to untreated diabetics. Serum total cholesterol, triglyceride, and HDL-cholesterol levels did not show a significant change in AU-treated diabetic rats as compared to untreated diabetics. On the other hand, LDL-cholesterol levels decreased in AU-treated diabetic group as compared to untreated diabetic group (p<0.05).Conclusion: Oral administration of AU has a significant hypoglycemic effect and in long term leads to decreased levels of serum LDL-cholesterol in diabetic rats.

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APA: Copy

FALLAHI, F., ROGHANI, M., & KHALILZAD, M.. (2011). HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ALLIUM URSINUM IN DIABETIC RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 19(1 (76)), 65-74. SID. https://sid.ir/paper/36422/en

Vancouver: Copy

FALLAHI F., ROGHANI M., KHALILZAD M.. HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ALLIUM URSINUM IN DIABETIC RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(1 (76)):65-74. Available from: https://sid.ir/paper/36422/en

IEEE: Copy

F. FALLAHI, M. ROGHANI, and M. KHALILZAD, “HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ALLIUM URSINUM IN DIABETIC RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 1 (76), pp. 65–74, 2011, [Online]. Available: https://sid.ir/paper/36422/en

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