INVOLVEMENT OF THE NITRIC OXIDE/L-ARGININGPATHWAY IN RELAXANT RESPONSES TO ADENOSINE
AND ADENINE NUCLEOTIDES

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KAVOLI HAGHIGHI M.

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Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 3 Page(s): 175-182

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Title

INVOLVEMENT OF THE NITRIC OXIDE/L-ARGININGPATHWAY IN RELAXANT RESPONSES TO ADENOSINE AND ADENINE NUCLEOTIDES

Author(s)

KAVOLI HAGHIGHI M. | Issue Writer Certificate

Keywords

ADENOSINEQ3

ADENINE NUCLEQTIDESQ4

NO/L-ARGQ4

L-NAME ENDOTHELIUMQ3

PULMONARY ARTERYQ4

Abstract

ADENOSINE and adenine nucleotides,(ADENOSINE 5-triphosphate (ATP) and ADENOSINE 5- diphosphate (ADP)) play an important role in the regulation of many biological processes including the control of vascular tone and homeostasis by interaction with specific receptors on the cell surface. The aims of this study were: I) investigation of responses of rat isolated PULMONARY ARTERY rings (main and branches)to these drugs; II) Possible involvement of nitric oxide L-arginine (No/L-Arg) pathway induced relaxant responses. The effects of ADENOSINE (AD), ADENOSINE diphosphate (ADP) and ADENOSINE triphosphate (ATP) were studied on artery rings precontracted with 100 nanomole phenylephrine (EC75). AD, ADP and ATP induced slowly developing endothelium -independent relaxations in these artery rings. Relaxant responses to AD were antagonised by the P1-receptor antagonist, theophylline. Pretreatment of arety rings with L-NAME did not affect relaxant responses to AD. Also mechanical removal of endothelium depressed only relaxant responses to 3 micromole AD. Relaxant responses to ADP and ATP were depressed in denuded endothelium artery rings or when they were pretreated with 200 micromole Nω nitro L-arginine methyl ester (L-NAME). In some experiments, L-NAME reversed relaxant responses to ADP and ATP; and these effects were inhibited by 1 milimole of L-arginine (L-Arg). Pretreatment of artery rings with glibenclamide (ATP-sensitive potassium channel blocker), theophylline (Purinergic receptor antagonist),indomethacin (prostacycline inhibitor) and propranolol (beta-adrenoceptor blocker) was not effective in relaxant responses to ADP or ATP. The results of this study showed that relaxant responses of rat PULMONARY ARTERY rings to AD were endothelium-independent and the NO/L-ARG pathway was not involved in relaxant responses. Also relaxant responses to AD were mediated by stimulation with purinergic P1 and Theophylline (purinergic-receptor antagonist) inhibited relaxant responses to ADP and ATP. This was endothelium-depented and the NO/L-ARG pathway was involved in relaxant responses. It is possible that relaxant responses to ATP or ADP were induced via P2-receptors.

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APA: Copy

KAVOLI HAGHIGHI, M.. (2001). INVOLVEMENT OF THE NITRIC OXIDE/L-ARGININGPATHWAY IN RELAXANT RESPONSES TO ADENOSINE AND ADENINE NUCLEOTIDES. KOWSAR MEDICAL JOURNAL, 6(part 3), 175-182. SID. https://sid.ir/paper/364344/en

Vancouver: Copy

KAVOLI HAGHIGHI M.. INVOLVEMENT OF THE NITRIC OXIDE/L-ARGININGPATHWAY IN RELAXANT RESPONSES TO ADENOSINE AND ADENINE NUCLEOTIDES. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 3):175-182. Available from: https://sid.ir/paper/364344/en

IEEE: Copy

M. KAVOLI HAGHIGHI, “INVOLVEMENT OF THE NITRIC OXIDE/L-ARGININGPATHWAY IN RELAXANT RESPONSES TO ADENOSINE AND ADENINE NUCLEOTIDES,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 3, pp. 175–182, 2001, [Online]. Available: https://sid.ir/paper/364344/en

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