THE EFFECT OF ORAL L-CARNITINE SUPPLEMENTATION ON LIPID PROFILES AND ANTIOXIDANT STATUS IN HEMODIALYSIS PATIENTS: A RANDOMIZED CLINICAL TRIAL

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AHMADI SEDIGHE; MOZAFFARI KHOSRAVI HASSAN; DEHGHAN BONADAKI SHIMA; NOORI MAJELAN NADER; LOTFI MOHAMMAD HASSAN

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:1 Page(s): 93-101

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Title

THE EFFECT OF ORAL L-CARNITINE SUPPLEMENTATION ON LIPID PROFILES AND ANTIOXIDANT STATUS IN HEMODIALYSIS PATIENTS: A RANDOMIZED CLINICAL TRIAL

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Keywords

HEMODIALYSISQ2

L-CARNITINEQ3

LIPID PROFILEQ1

TOTAL ANTI OXIDANT CAPACITYQ1

Abstract

Introduction: Dyslipidemia and oxidative stress are commonly seen in the patients undergoing HEMODIALYSIS. This study aimed to evaluate the effect of oral L-CARNITINE supplementation on LIPID PROFILEs and total antioxidant capacity of the patients were treated with HEMODIALYSIS.Methods: This study was a randomized, controlled clinical trial. The participants of this study consisted of 50 HEMODIALYSIS patients in dialysis centers of Yazd between 2013 and 2014. The patients randomly divided into two groups; L-CARNITINE (LG) and control group (CG). The patients in the LG were instructed to use daily 1g L-CARNITINE oral supplementation, as syrup for 12 weeks. The patients in the CG did not receive any supplement containing L-CARNITINE. At the baseline and the end of 12 weeks, triglycerides, total cholesterol (TC), LDLc, and total antioxidant capacity of serum (TAC) were evaluated in both groups.Results: The mean of triglyceride and TC between and within groups were not significantly different. The mean of LDLc did not change in LG whereas a significant increase was seen in CG (p=0.02). The mean differences of LDLc between groups was statistically significant (p=0.05). No Significant changes were observed in serum levels of TAC in LG compared with CG (p=0.76). TAC was increased in both groups, but these changes were not statistically significant (p=0.62).Conclusions: This study showed that oral supplementation of L-CARNITINE as syrup (1g per day) for 12 weeks among the HEMODIALYSIS patients would have no effect on triglyceride, TC, and TAC, but it would decrease the LDLc.

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APA: Copy

AHMADI, SEDIGHE, MOZAFFARI KHOSRAVI, HASSAN, DEHGHAN BONADAKI, SHIMA, NOORI MAJELAN, NADER, & LOTFI, MOHAMMAD HASSAN. (2016). THE EFFECT OF ORAL L-CARNITINE SUPPLEMENTATION ON LIPID PROFILES AND ANTIOXIDANT STATUS IN HEMODIALYSIS PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(1), 93-101. SID. https://sid.ir/paper/36463/en

Vancouver: Copy

AHMADI SEDIGHE, MOZAFFARI KHOSRAVI HASSAN, DEHGHAN BONADAKI SHIMA, NOORI MAJELAN NADER, LOTFI MOHAMMAD HASSAN. THE EFFECT OF ORAL L-CARNITINE SUPPLEMENTATION ON LIPID PROFILES AND ANTIOXIDANT STATUS IN HEMODIALYSIS PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(1):93-101. Available from: https://sid.ir/paper/36463/en

IEEE: Copy

SEDIGHE AHMADI, HASSAN MOZAFFARI KHOSRAVI, SHIMA DEHGHAN BONADAKI, NADER NOORI MAJELAN, and MOHAMMAD HASSAN LOTFI, “THE EFFECT OF ORAL L-CARNITINE SUPPLEMENTATION ON LIPID PROFILES AND ANTIOXIDANT STATUS IN HEMODIALYSIS PATIENTS: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 1, pp. 93–101, 2016, [Online]. Available: https://sid.ir/paper/36463/en

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