Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Adineh Ahmad; ARBABI BIDGOLI SEPIDEH; AMIN GHOLAMREZA; GHAFFARI SOLMAZ

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Yafteh Year:2020 | Volume:22 | Issue:3 (85) Page(s): 34-47

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

803

Download:

Cites:

Information Journal Paper

Title

Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat

Author(s)

Adineh Ahmad | ARBABI BIDGOLI SEPIDEH | AMIN GHOLAMREZA | GHAFFARI SOLMAZ | Issue Writer Certificate

Keywords

Kelussia odoratissima MozaffQ2

KelussiaQ2

Acute toxicityQ1

Repeated dose toxicityQ2

Essential OilQ1

KlowsQ1

Abstract

Background: We aimed in this study to evaluate the acute and Repeated dose toxicity of Kelussia odoratissima Mozaff/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopathological effects of the herb’ s Essential Oil, aerial parts of this plant were collected from Shahrekord in spring 2019. After careful evaluation and issuing the Herbarium Code Number, herb’ s dry powder was provided and the Essential Oil was prepared by Clevenger apparatus. Acute and Repeated dose toxicity tests were performed by OECD 423 and 407 guidelines through intraperitoneal (i. p. ) injections to female rats. Results: Acute test didn’ t show any sign of toxicity in doses up to 2000 mg/kg and in delayed Acute toxicity assessment no sign of toxic reaction was recorded. In repeated dose test all animals in two different dose groups (5 and 50 mg/kg) survived healthy according to the clinical, biochemical, hematological, necropsy and histopathological studies. Significant weight increase in high dose group (50 mg /kg/day) was accompanied with hepatotoxic reactions compared to vehicle control group (distilled water). Low dose group (5 mg/kg /day) showed significant biochemical changes in relevant nephrotoxicity related biomarkers which were not accompanied with histopathological evidence. Conclusion: The results of this study showed that oral long term administration of Kelussia Essential Oil could be considered as a safe herbal remedy in doses up to 5 mcg/kg/day for human medical and nutritional purposes.

Cites

No record.

References

Cite

APA: Copy

Adineh, Ahmad, ARBABI BIDGOLI, SEPIDEH, & GHAFFARI, SOLMAZ. (2020). Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat. YAFTEH, 22(3 (85) ), 34-47. SID. https://sid.ir/paper/365209/en

Vancouver: Copy

Adineh Ahmad, ARBABI BIDGOLI SEPIDEH, GHAFFARI SOLMAZ. Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat. YAFTEH[Internet]. 2020;22(3 (85) ):34-47. Available from: https://sid.ir/paper/365209/en

IEEE: Copy

Ahmad Adineh, SEPIDEH ARBABI BIDGOLI, and SOLMAZ GHAFFARI, “Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat,” YAFTEH, vol. 22, no. 3 (85) , pp. 34–47, 2020, [Online]. Available: https://sid.ir/paper/365209/en

Related Journal Papers