ASSOCIATION BETWEEN CPEB1 GENE POLYMORPHISM AND IRANIAN MALE INFERTILITY

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YADOLLAHYKHALESS ATEFE; KALHOR NASER; ATRI ROOZBAHANI GOLNAZ

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:8 Page(s): 612-620

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Title

ASSOCIATION BETWEEN CPEB1 GENE POLYMORPHISM AND IRANIAN MALE INFERTILITY

Author(s)

YADOLLAHYKHALESS ATEFE | KALHOR NASER | ATRI ROOZBAHANI GOLNAZ | Issue Writer Certificate

Keywords

MALE INFERTILITYQ2

SINGLE NUCLEOTID POLYMORPHISMQ2

CPEB1 GENEQ1

Abstract

Introduction: Spermatogenesis is a strictly regulated process in sperm production that is needed for sperm production transcriptional and posttranscriptional regulations. The cytoplasmic polyadenylation element binding (CPEB) protein regulates cytoplasmic polyadenylation of mRNAs in oogenesis and spermatogenesis. The purpose of the present studywas examining the association between rs2303846, which is located at 3' UTR of CPEB gene, and Iranian MALE INFERTILITY.Methods: In this case–control analysis, 140 blood samples were collected (70 fertile men and 70 infertile men). rs2303846 genotypes were determined by PCR-RFLP method and the results were confirmed by sequencing. The differences in genotype distributions between cases and fertile controls were examined using Chi-squared analysis and SNPSTAT software. Corelation between this SNP and miRNAs was examined.Results: TT genotype was observed in 5 infertile men among 70 case samples, while all control samples showed CC genotype and there was a significant association in this difference (P=0.023). This SNP exist in seed region of three miRNAs (hsa-miR-143-5p, hsa-miR- 6511b-5p, hsa-miR-3944-5p) and T allele causes seed destruction. In addition, T allele leads to the loose binding of all the selected miRNAs.Conclusion: Our results indicate that rs2303846, which is located on CPEB1 is associated with the risk of infertility in Iranian population. Our bioinformatics analysis showed that changing the T allele of rs2303846, instead of C allele could loose miRNA binding to their target genes in our selected miRNAs. Consequently, the gene is stable and its expression continues.

Cites

Study the Association Between CPEB2 Gene Polymorphism with the Risk of Idiopathic Azoospermia/Severe Oligozoospermia of Men

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APA: Copy

YADOLLAHYKHALESS, ATEFE, KALHOR, NASER, & ATRI ROOZBAHANI, GOLNAZ. (2017). ASSOCIATION BETWEEN CPEB1 GENE POLYMORPHISM AND IRANIAN MALE INFERTILITY. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(8 ), 612-620. SID. https://sid.ir/paper/36542/en

Vancouver: Copy

YADOLLAHYKHALESS ATEFE, KALHOR NASER, ATRI ROOZBAHANI GOLNAZ. ASSOCIATION BETWEEN CPEB1 GENE POLYMORPHISM AND IRANIAN MALE INFERTILITY. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(8 ):612-620. Available from: https://sid.ir/paper/36542/en

IEEE: Copy

ATEFE YADOLLAHYKHALESS, NASER KALHOR, and GOLNAZ ATRI ROOZBAHANI, “ASSOCIATION BETWEEN CPEB1 GENE POLYMORPHISM AND IRANIAN MALE INFERTILITY,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 8 , pp. 612–620, 2017, [Online]. Available: https://sid.ir/paper/36542/en

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