COMPARISON OF THE NUMBER OF PERIPHERAL BLOOD CD4+CD25+ T CELLS IN UNEXPLAINED RECURRENT SPONTANEOUS ABORTION PATIENTS WITH NORMAL PREGNANT WOMEN

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MOZAYYANI R.; BAHAR ARA J.; MOUSAVIFAR N.; ESLAMI M.; ESLAMI A.; RASTIN N.; SHEIKH A.; TABASI N.; MAHMOUDI M.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2011 | Volume:19 | Issue:2 (77) Page(s): 192-200

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Title

COMPARISON OF THE NUMBER OF PERIPHERAL BLOOD CD4+CD25+ T CELLS IN UNEXPLAINED RECURRENT SPONTANEOUS ABORTION PATIENTS WITH NORMAL PREGNANT WOMEN

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Keywords

ABORTIONQ3

HABITUALQ2

ABORTIONQ3

SPONTANEOUSQ3

T- LYMPHOCYTOPENIAQ3

IDIOPATHIC CD4- POSITIVEQ3

PREGNANCYQ3

Abstract

Introduction: Undoubtedly, reproduction is a necessity for survival and successful PREGNANCY is an immunological paradox. In the present study, we investigated the proportional changes of CD4+CD25bright T cells, CD4+CD25dim T cells in peripheral blood in unexplained recurrent SPONTANEOUS ABORTIONs (URSA) and compared it with normal pregnant women by antibody monoclonal method.Methods: The study group comprised of women with miscarriages of unexplained etiology who had normal karyotypes, anticardiolipin antibodies, prolactin levels and normal spousal spermograms. They did not have polycystic ovaries and also did not receive any drugs at the time of the study. PBLs lymphocytes were isolated, then FITC-conjugated and anti-CD4 and PE-conjugated anti-CD25 antibody levels were measured. Then results of the study and control group were analyzed and compared.Results: The absolute number of CD25 bright cells in the CD4+T cells in peripheral blood was statistically significantly lower in the study group as compared to the control group (P=0.000). The absolute number of CD4+CD25dimT cells in peripheral blood was statistically significantly higher in the study group as compared to the control group (P=0.000).Conclusion: As decrease in the number of CD4+CD25+Tcells or their functional deficiency may be linked with miscarriage, CD4+CD25+Tells could serve as a novel biomarker for monitoring in URSA patients, but more studies are needed in this field.

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APA: Copy

MOZAYYANI, R., BAHAR ARA, J., MOUSAVIFAR, N., ESLAMI, M., ESLAMI, A., RASTIN, N., SHEIKH, A., TABASI, N., & MAHMOUDI, M.. (2011). COMPARISON OF THE NUMBER OF PERIPHERAL BLOOD CD4+CD25+ T CELLS IN UNEXPLAINED RECURRENT SPONTANEOUS ABORTION PATIENTS WITH NORMAL PREGNANT WOMEN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 19(2 (77)), 192-200. SID. https://sid.ir/paper/36552/en

Vancouver: Copy

MOZAYYANI R., BAHAR ARA J., MOUSAVIFAR N., ESLAMI M., ESLAMI A., RASTIN N., SHEIKH A., TABASI N., MAHMOUDI M.. COMPARISON OF THE NUMBER OF PERIPHERAL BLOOD CD4+CD25+ T CELLS IN UNEXPLAINED RECURRENT SPONTANEOUS ABORTION PATIENTS WITH NORMAL PREGNANT WOMEN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(2 (77)):192-200. Available from: https://sid.ir/paper/36552/en

IEEE: Copy

R. MOZAYYANI, J. BAHAR ARA, N. MOUSAVIFAR, M. ESLAMI, A. ESLAMI, N. RASTIN, A. SHEIKH, N. TABASI, and M. MAHMOUDI, “COMPARISON OF THE NUMBER OF PERIPHERAL BLOOD CD4+CD25+ T CELLS IN UNEXPLAINED RECURRENT SPONTANEOUS ABORTION PATIENTS WITH NORMAL PREGNANT WOMEN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2 (77), pp. 192–200, 2011, [Online]. Available: https://sid.ir/paper/36552/en

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