Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats

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Saeedi sadra; RAFIEIRAD MARYAM

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Journal: Feyz Medical Sciences Journal Year:2020 | Volume:24 | Issue:3 Page(s): 245-253

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Title

Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats

Author(s)

Saeedi sadra | RAFIEIRAD MARYAM | Issue Writer Certificate

Keywords

AnxietyQ2

Alpha-pineneQ1

DiazepamQ3

RatQ2

Abstract

Background: Considering the side effects of anti-Anxiety drugs, this study investigated the effect of Alpha-pinene on Anxiety behaviors compared with Diazepam in Rats. Materials and Methods In this study, 40 male Wistar Rats were divided into 5 groups: control, sham (received alphapinene solvent), the groups received 2 and 4 mg/kg alphapinene, and the group that received Diazepam 10 mg/kg. At the end of this period, Anxiety was measured using elevated plus maze and concentRations of malondialdehyde, thiol and glutathione peroxidase, in hippocampal tissue. The results were analyzed using one-way ANOVA and Tukey tests. Results: In the groups receiving 2 and 4 mg/kg doses of Alpha-pinene significantly increased the percentage of open arm entry (P<0. 001) and percentage of time spent in the open arm (P<0. 05) (P<0. 05). Compared to the control and Diazepam groups, administRation of alphapinene significantly decreased MDA concentRation (P<0. 001) and significant increase in thiol (P<0. 01) (P<0. 05) and glutathione peroxidase enzyme activity was evident (P<0. 001). Conclusion: Alpha-pinene showed a downward effect on Anxiety responses in male Rats, similar to anxiolytic effects of Diazepam. Alpha-pinene may be potentiated by binding to the position of benzodiazepines in GABA A receptors and exerted its anti-Anxiety effect with antioxidant properties.

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APA: Copy

Saeedi, sadra, & RAFIEIRAD, MARYAM. (2020). Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats. FEYZ, 24(3 ), 245-253. SID. https://sid.ir/paper/365720/en

Vancouver: Copy

Saeedi sadra, RAFIEIRAD MARYAM. Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats. FEYZ[Internet]. 2020;24(3 ):245-253. Available from: https://sid.ir/paper/365720/en

IEEE: Copy

sadra Saeedi, and MARYAM RAFIEIRAD, “Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats,” FEYZ, vol. 24, no. 3 , pp. 245–253, 2020, [Online]. Available: https://sid.ir/paper/365720/en

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