Istopathological and Biochemical Effects of Thiamine Administration on Mice Liver Exposure by the Copper Oxide and Copper Oxide Nanoparticles

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FATAHIAN DEHKORDI R.A.; HEIDARNEJAD M.S.; MOHEBBI A.N.; Mosayebi F.

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Journal: Journal of Animal Research Year:2017 | Volume:30 | Issue:2 Page(s): 0-0

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Title

Istopathological and Biochemical Effects of Thiamine Administration on Mice Liver Exposure by the Copper Oxide and Copper Oxide Nanoparticles

Author(s)

FATAHIAN DEHKORDI R.A. | HEIDARNEJAD M.S. | MOHEBBI A.N. | Mosayebi F. | Issue Writer Certificate

Keywords

ThiamineQ1

MouseQ2

Oxide copperQ1

Copper nanoparticlesQ1

LiverQ2

Abstract

The aim of this study was to assess biochemical and histopathological effects of coadministration of Thiamine and copper oxide and copper nanoprticles on the Liver Mouse. A total of the 30 adult mice were randomly divided into 5 groups (6 mice per each group) and considers on days 0, 10 and 20. Group A served control. Copper oxide and copper oxide nanoparticles (0. 2 mg/kg) was injected intraperitoneally to groups B and C, respectively. The mice in groups E and D received the similar dose of copper oxide and Copper nanoparticles along with Thiamine (30 mg/l). As a result, influence of blood cells into Liver sinusoids and inflammatory cells infiltration (neutrophil and lymphocyte) around the veins in groups B and C were observed. These abnormalities were less evident in the groups receiving Thiamine to the extent that was near to control group. Significant differences were observed in the amount of catalase and superoxide dismutase in groups B and C on day 20 than to the control group. TBARS values in groups B and C on days 10 and 20 and in Group E at day 20 was significantly increased compared to control group. As a result, copper oxide nanoparticles causes damage to the Liver and Thiamine reducing the effects of the concurrent administration.

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APA: Copy

FATAHIAN DEHKORDI, R.A., HEIDARNEJAD, M.S., MOHEBBI, A.N., & Mosayebi, F.. (2017). Istopathological and Biochemical Effects of Thiamine Administration on Mice Liver Exposure by the Copper Oxide and Copper Oxide Nanoparticles. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(2 ), 0-0. SID. https://sid.ir/paper/366295/en

Vancouver: Copy

FATAHIAN DEHKORDI R.A., HEIDARNEJAD M.S., MOHEBBI A.N., Mosayebi F.. Istopathological and Biochemical Effects of Thiamine Administration on Mice Liver Exposure by the Copper Oxide and Copper Oxide Nanoparticles. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(2 ):0-0. Available from: https://sid.ir/paper/366295/en

IEEE: Copy

R.A. FATAHIAN DEHKORDI, M.S. HEIDARNEJAD, A.N. MOHEBBI, and F. Mosayebi, “Istopathological and Biochemical Effects of Thiamine Administration on Mice Liver Exposure by the Copper Oxide and Copper Oxide Nanoparticles,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 2 , pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/366295/en

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