A New Approach to Virulence Factors of Candida albicans: From Gene to Function

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Davari Amirhossein; Ahmadkhani Fardin; Jafarzadeh Jalal; Mirzakhani Roghayeh; Roodgari Somayeh; BAGHERI SOGHRA; NABILI MOJTABA; MOAZENI MARYAM

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Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:29 | Issue:178 Page(s): 181-196

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Title

A New Approach to Virulence Factors of Candida albicans: From Gene to Function

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Keywords

Candida albicansQ2

virulenceQ3

gene expression regulationQ1

Abstract

Recently, there is an increasing trend in the diversity of pathogenic yeasts isolated from clinical samples. However, Candida albicans is even now the major cause of yeast infections. Candida albicans is one of the members of the mucosal microbiota which can cause cutaneous, mucosal, and disseminated invasive infections in susceptible individuals. For persistence in the host, the yeast must have the ability to adhere to both biotic and abiotic surfaces following host tissue invasion, and obtain iron. One of the important properties of this pathogenic yeast is dimorphism which is its ability to switch from a unicellular to a hyphal mode of growth. Dimorphism is triggered in response to certain environmental conditions, such as pH alternation, temperature, or serum availability. These changes which allow the yeast to invade are associated with the expression of several genes involving in its pathogenesis, including SAP genes family encoding the secreted aspartic proteinases (Saps), the agglutinin-like sequence (ALS) family encoding the adhessive proteins, and phenotypic and morphologic switching systems. This review aimed at summarizing recent data on the regulation and relevant signal transduction of some important essential genes associated with virulence factors in Candid albicans. Surely, understanding the genetic of the virulence factors would be of great benefit in effective combating the yeast and also in designing new antifungal agents.

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APA: Copy

Davari, Amirhossein, Ahmadkhani, Fardin, Jafarzadeh, Jalal, Mirzakhani, Roghayeh, Roodgari, Somayeh, BAGHERI, SOGHRA, NABILI, MOJTABA, & MOAZENI, MARYAM. (2019). A New Approach to Virulence Factors of Candida albicans: From Gene to Function. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(178 ), 181-196. SID. https://sid.ir/paper/366489/en

Vancouver: Copy

Davari Amirhossein, Ahmadkhani Fardin, Jafarzadeh Jalal, Mirzakhani Roghayeh, Roodgari Somayeh, BAGHERI SOGHRA, NABILI MOJTABA, MOAZENI MARYAM. A New Approach to Virulence Factors of Candida albicans: From Gene to Function. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(178 ):181-196. Available from: https://sid.ir/paper/366489/en

IEEE: Copy

Amirhossein Davari, Fardin Ahmadkhani, Jalal Jafarzadeh, Roghayeh Mirzakhani, Somayeh Roodgari, SOGHRA BAGHERI, MOJTABA NABILI, and MARYAM MOAZENI, “A New Approach to Virulence Factors of Candida albicans: From Gene to Function,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 178 , pp. 181–196, 2019, [Online]. Available: https://sid.ir/paper/366489/en

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