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Title

EFFECT OF ENDURANCE EXERCISE ON ANTIOXIDANT ENZYME ACTIVITIES AND LIPID PEROXIDATION IN THE HEART OF THE STREPTOZOTOCIN-INDUCED DIABETIC RATS

Pages

  798-809

Abstract

 Introduction: OXIDATIVE STRESS can promote the development of complications of diabetes. Moderate exercise improves cardiac antioxidant status in diabetic animals. The current study aimed to investigate the effect of 8 week endurance exercise training on some heart antioxidant enzyme activities and LIPID PEROXIDATION of HEART TISSUE in streptozotocin-induced diabetic rats.Methods: To this end, 30 male Wistar rats were randomly divided into 3 groups: the healthy control group (C), diabetic control group (DC) and trained diabetic group (TD). Animals in TD group were exercised on a treadmill 4 days a week for 8 weeks. After 8 weeks, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and malondialdehyde (MDA) levels were measured in HEART TISSUEs. The data were analyzed using one- way ANOVA (p<0.05).Results: The CAT and GPx activities of the HEART TISSUE in DC group were found to be significantly higher (p=0.000) in compared with C group, whereas SOD activity was not found significantly different among the experimental groups. Also, heart GPx activity in TD group was significantly lower (p=0.000) than that of DC group, while CAT activity was not affected by ENDURANCE TRAINING. After 8-week endurance exercise (TD group), the MDA levels of HEART TISSUE were significantly higher (respectively p<0.017 and p=0.000) than C and DC groups.Conclusion: The results of the present study have demonstrated that due to decreased GPx activities and MDA levels, endurance exercise may make the HEART TISSUE more susceptible to OXIDATIVE STRESS.

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    APA: Copy

    FARHANGI, NEGIN, NAZEM, FARZAD, & ZEHSAZ, FARZAD. (2017). EFFECT OF ENDURANCE EXERCISE ON ANTIOXIDANT ENZYME ACTIVITIES AND LIPID PEROXIDATION IN THE HEART OF THE STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(10), 798-809. SID. https://sid.ir/paper/36693/en

    Vancouver: Copy

    FARHANGI NEGIN, NAZEM FARZAD, ZEHSAZ FARZAD. EFFECT OF ENDURANCE EXERCISE ON ANTIOXIDANT ENZYME ACTIVITIES AND LIPID PEROXIDATION IN THE HEART OF THE STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(10):798-809. Available from: https://sid.ir/paper/36693/en

    IEEE: Copy

    NEGIN FARHANGI, FARZAD NAZEM, and FARZAD ZEHSAZ, “EFFECT OF ENDURANCE EXERCISE ON ANTIOXIDANT ENZYME ACTIVITIES AND LIPID PEROXIDATION IN THE HEART OF THE STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 10, pp. 798–809, 2017, [Online]. Available: https://sid.ir/paper/36693/en

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