INVOLVEMENT OF NITRIC OXIDE PATHWAY IN MEDIATING PAIN IN MICE

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FATEHI M.; RAZAVI M.T.; FATEHI HASSANABAD Z.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2001 | Volume:4 | Issue:2 (10) Page(s): 4-7

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Information Journal Paper

Title

INVOLVEMENT OF NITRIC OXIDE PATHWAY IN MEDIATING PAIN IN MICE

Author(s)

FATEHI M. | RAZAVI M.T. | FATEHI HASSANABAD Z. | Issue Writer Certificate

Keywords

PAINQ2

TAIL FLICKQ4

HOT PLATEQ4

NITRIC OXIDEQ2

L-NAMEQ4

MORPHINEQ4

Abstract

The effect of L-NAME, a NITRIC OXIDE inhibitor and indomethacin, a non selective cyclooxyganes inhibitor on PAINful stimuli were investigated in mice employing TAIL FLICK latency measurement and HOT PLATE technique. Mice were injected with different doses of L-NAME (0.2, 0.5 and 0.8 mg/100g). The TAIL FLICK latency and response time to the HOT PLATE chamber were significantly increased in L-NAME (0.5 mg/100g) -treated mice. However, the effects of L-NAME were reversed by the administration of L-arginine (5 mg/100g). Indomethacin injection caused a non-significant increase in tolerance to PAINful stimuli. These results may suggest that attenuation of PAIN in mice is partly through the activation of L-arginine NITRIC OXIDE pathway.

Cites

SEX AFFECTS THE FEELING OF PAIN IN THE MICE, POSSIBLE INVOLVEMENT OF NITRIC OXIDE

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APA: Copy

FATEHI, M., RAZAVI, M.T., & FATEHI HASSANABAD, Z.. (2001). INVOLVEMENT OF NITRIC OXIDE PATHWAY IN MEDIATING PAIN IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 4(2 (10)), 4-7. SID. https://sid.ir/paper/367011/en

Vancouver: Copy

FATEHI M., RAZAVI M.T., FATEHI HASSANABAD Z.. INVOLVEMENT OF NITRIC OXIDE PATHWAY IN MEDIATING PAIN IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2001;4(2 (10)):4-7. Available from: https://sid.ir/paper/367011/en

IEEE: Copy

M. FATEHI, M.T. RAZAVI, and Z. FATEHI HASSANABAD, “INVOLVEMENT OF NITRIC OXIDE PATHWAY IN MEDIATING PAIN IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 4, no. 2 (10), pp. 4–7, 2001, [Online]. Available: https://sid.ir/paper/367011/en

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