A Comparative Histopathological Investigation of the Effects of ZnO/ Chitosan Nanocomposites and ZnO Nanoparticles on Thioacetamide-induced Nephrophaty in Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJINEZHAD MOHAMMAD REZA; JAMSHIDIAN ABBAS; SAMZADEH KERMANI ALIREZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:29 | Issue:176 Page(s): 189-194

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

372

Download:

Cites:

Information Journal Paper

Title

A Comparative Histopathological Investigation of the Effects of ZnO/ Chitosan Nanocomposites and ZnO Nanoparticles on Thioacetamide-induced Nephrophaty in Rats

Author(s)

HAJINEZHAD MOHAMMAD REZA | JAMSHIDIAN ABBAS | SAMZADEH KERMANI ALIREZA | Issue Writer Certificate

Keywords

liverQ2

ZnO/chitosan nanoparticlesQ1

ZnO nanocompositesQ1

kidneyQ2

ratQ1

Abstract

Background and purpose: This study compared the effects of intraperitoneal injections of ZnO/chitosan nanocomposite and ZnO nanoparticles on histopathology of kidney in thioacetamideintoxicated rats. Materials and methods: Twenty-eight male rats were randomly allocated into a healthy control group (negative control), positive control group (thioacetamide-intoxicated rats), thioacetamideintoxicated + ZnO nanoparticles, and thioacetamide-iontoxicated + ZnO/chitosan nanocomposite. Nephropathy was induced by intraperitoneal injection of thioacetamide (50 mg/kg IP) three times (24h interval). The treatment groups were treated with ZnO nanocomposites (5mg/kg) and ZnO nanoparticles (5mg/kg) intraperitoneally for four weeks. Then, serum BUN and creatinine levels were measured. Afterwards, the rats were euthanized and kidney samples were separated for histological examinations. Results: There were significant increases in serum BUN and creatinine levels in thioacetamideintoxicated rats compared to those in the control group (P<0. 05). Compared to the control group, ZnO nanoparticles – treated group was found with significantly higher serum BUN and creatinine levels (P<0. 05). There was no significant difference between the rats treated with ZnO/chitosan nanocomposites and the positive control group in BUN and creatinine levels (P>0. 05). In histological analysis, tubular necrosis and glomerular fibrosis were observed in treatment groups. Conclusion: This study showed that ZnO nanoparticles can increase nephrotoxicity induced by thioacetamide, but, ZnO/chitosan nanocomposite had no effect on thioacetamide induced nephrotoxicity.

Cites

No record.

References

No record.

Cite

APA: Copy

HAJINEZHAD, MOHAMMAD REZA, JAMSHIDIAN, ABBAS, & SAMZADEH KERMANI, ALIREZA. (2019). A Comparative Histopathological Investigation of the Effects of ZnO/ Chitosan Nanocomposites and ZnO Nanoparticles on Thioacetamide-induced Nephrophaty in Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(176), 189-194. SID. https://sid.ir/paper/367471/en

Vancouver: Copy

HAJINEZHAD MOHAMMAD REZA, JAMSHIDIAN ABBAS, SAMZADEH KERMANI ALIREZA. A Comparative Histopathological Investigation of the Effects of ZnO/ Chitosan Nanocomposites and ZnO Nanoparticles on Thioacetamide-induced Nephrophaty in Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(176):189-194. Available from: https://sid.ir/paper/367471/en

IEEE: Copy

MOHAMMAD REZA HAJINEZHAD, ABBAS JAMSHIDIAN, and ALIREZA SAMZADEH KERMANI, “A Comparative Histopathological Investigation of the Effects of ZnO/ Chitosan Nanocomposites and ZnO Nanoparticles on Thioacetamide-induced Nephrophaty in Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 176, pp. 189–194, 2019, [Online]. Available: https://sid.ir/paper/367471/en

Related Journal Papers