Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats

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Ilkhani Amir Bagher; TEHRANIPOUR MARYAM; Balanezhad Saeedeh Zafar

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Journal: Journal of Gorgan University of Medical Sciences Year:2020 | Volume:22 | Issue:1 (73) Page(s): 57-64

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Title

Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats

Author(s)

Ilkhani Amir Bagher | TEHRANIPOUR MARYAM | Balanezhad Saeedeh Zafar | Issue Writer Certificate

Keywords

DiazepamQ3

SpermatogenesisQ2

FertilityQ2

RatQ2

Abstract

Background and Objective: Sperm dysfunction and damage in Spermatogenesis are the most common causes of male inFertility. Diazepam is also a painkiller for benzodiazepines that can be addictive for a long time. This study was done to determine the effect of Diazepam on testicular tissue parameters and Spermatogenesis in Rats. Methods: In this experimental study, 30 Wistar male Rats with a 250-200 gram weight were randomly allocated into 5 groups. Experimental groups were received Diazepam with doses of (2, 3, 4, 5 mg/kg/bw) for 14 days, intraperitonally. Serum physiology was injected in control group. The animals were anesthetized and the testes and epididymis ductus defran were removed for examination, sperm motility, and percentage of live sperm. Results: Weight, large and small testicular diameter, percentage of live sperm and number of sperm moving forward were reduced with injection groups, at a dose of 3 mg / kg in all factors except the number of sperm moving forward in compared to the control group. In other groups, only testicular weight was significantly reduced at a dose of 2 mg/kg (P<0. 05). Conclusion: Diazepam can affect Spermatogenesis process in Rats.

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References

Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats

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APA: Copy

Ilkhani, Amir Bagher, TEHRANIPOUR, MARYAM, & Balanezhad, Saeedeh Zafar. (2020). Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 22(1 (73) ), 57-64. SID. https://sid.ir/paper/367682/en

Vancouver: Copy

Ilkhani Amir Bagher, TEHRANIPOUR MARYAM, Balanezhad Saeedeh Zafar. Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;22(1 (73) ):57-64. Available from: https://sid.ir/paper/367682/en

IEEE: Copy

Amir Bagher Ilkhani, MARYAM TEHRANIPOUR, and Saeedeh Zafar Balanezhad, “Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 1 (73) , pp. 57–64, 2020, [Online]. Available: https://sid.ir/paper/367682/en

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