STUDY OF OKRA POWDER (ABELMOSCUS ESCULENTUS) EFFECTS ON HISTOLOGY OF LIVER TISSUE AND SERO-BIOCHEMICAL PARAMETERS IN DIABETIC RATS (HFD/STZ)

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ERFANI MAJD NAEEM; SHAHRIARI ALI; TABANDEH MOHAMMAD REZA; SOLEIMANI ZAHRA

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:9 Page(s): 690-705

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Title

STUDY OF OKRA POWDER (ABELMOSCUS ESCULENTUS) EFFECTS ON HISTOLOGY OF LIVER TISSUE AND SERO-BIOCHEMICAL PARAMETERS IN DIABETIC RATS (HFD/STZ)

Author(s)

ERFANI MAJD NAEEM | SHAHRIARI ALI | TABANDEH MOHAMMAD REZA | SOLEIMANI ZAHRA | Issue Writer Certificate

Keywords

TYPE 2 DIABETESQ2

HISTOLOGYQ2

BIOCHEMICALQ2

INSULIN RESISTANCEQ2

OKRAQ2

LIVERQ2

RATQ2

Abstract

Introduction: Type 2 diabete is a kind of metabolic disease that it is associated with hyperglycemia, hyperlipidemia and disturbed LIVER function. The aim of the present study was to evaluate the protective effects of OKRA Powder on LIVER damage in high fat diet fed / streptozotocin (HFD-STZ)-induced type 2 diabetic RATsMethods: In this experimental study, 25 Wistar Albino female RATs with an average weight of (200–220 g) were randomly divided into 5 groups: Group I: (control group) RATs were fed the standard diet, Group II: healthy RATs that received OKRA Powder (200 mg/kg) for 4 weeks; Group III (HFD/STZ group): RATs were fed with high-fat diet (HFD) (60% fat) for 4 weeks and then injected low dose of STZ (35 mg/kg), Group IV: Diabetic RATs that received OKRA Powder (200 mg/kg) for 4 weeks. GroupV: Diabetic RATs that received metformin (200 mg/kg) for 4 weeks. At the end of experiment, BIOCHEMICAL parameters were measured. LIVER samples were removed and 5-6 µ sections were made and stained by H&E and Sudan black staining.Results: The results showed that all the BIOCHEMICAL parameters, except HDL-C and serum insulin were increased in diabetic RATs, while they were decreased in OKRA supplementation group compared to diabetic RATs (p<0.05). The LIVER structure alterations were improved in treated diabetic RATs with OKRA Powder and metformin.Conclusion: Our findings confirmed the potential anti-hyperglycemic and hypolipidemic effects of OKRA Powder. Thus, it seems it has an important role in the management of type 2 diabete.

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APA: Copy

ERFANI MAJD, NAEEM, SHAHRIARI, ALI, TABANDEH, MOHAMMAD REZA, & SOLEIMANI, ZAHRA. (2016). STUDY OF OKRA POWDER (ABELMOSCUS ESCULENTUS) EFFECTS ON HISTOLOGY OF LIVER TISSUE AND SERO-BIOCHEMICAL PARAMETERS IN DIABETIC RATS (HFD/STZ). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(9), 690-705. SID. https://sid.ir/paper/36785/en

Vancouver: Copy

ERFANI MAJD NAEEM, SHAHRIARI ALI, TABANDEH MOHAMMAD REZA, SOLEIMANI ZAHRA. STUDY OF OKRA POWDER (ABELMOSCUS ESCULENTUS) EFFECTS ON HISTOLOGY OF LIVER TISSUE AND SERO-BIOCHEMICAL PARAMETERS IN DIABETIC RATS (HFD/STZ). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(9):690-705. Available from: https://sid.ir/paper/36785/en

IEEE: Copy

NAEEM ERFANI MAJD, ALI SHAHRIARI, MOHAMMAD REZA TABANDEH, and ZAHRA SOLEIMANI, “STUDY OF OKRA POWDER (ABELMOSCUS ESCULENTUS) EFFECTS ON HISTOLOGY OF LIVER TISSUE AND SERO-BIOCHEMICAL PARAMETERS IN DIABETIC RATS (HFD/STZ),” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 9, pp. 690–705, 2016, [Online]. Available: https://sid.ir/paper/36785/en

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