Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly

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GHAHRAMANI P.; ESHAGH HAROONI H.; FATEMI TABATABAEI S.R.; MOAZEDI A.A.

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Journal: Journal of Animal Research Year:2018 | Volume:30 | Issue:4 Page(s): 0-0

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Title

Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly

Author(s)

GHAHRAMANI P. | ESHAGH HAROONI H. | FATEMI TABATABAEI S.R. | MOAZEDI A.A. | Issue Writer Certificate

Keywords

AnxietyQ2

OvariectomizedQ2

peri-pubertalyQ1

GonadectomizedQ2

zinc chlorideQ1

Abstract

Previous studies have shown that the anxiolytic effects of different zinc chloride in male and female rats is Castration post-pubertaly. This study, the effect of zinc chloride on Anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly was investigated. In this experiment, fifty female rats were Ovariectomized at postnatal day 21-22 and then on postnatal day 75, different doses of zinc chloride (0, 5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. Ovarectomized significantly decreased the time spent in the open arms in ovarectomized rats compared to the sham group (P<0. 05). zinc chloride (5 mg/kg) Significantly increase the number of entries in the open arms in ovarectomized (5 mg/kg) group compared to the ovarectomized (0 mg/kg) group (P<0. 05). Ovarectomized not Significantly the latency to immobility and total immobility time compared to the sham group. zinc chloride (10, 20 mg/kg) Significantly reduced the latency to immobility in ovarectomized (10, 20 mg/kg) group compared to the ovarectomized (0 mg/kg) group (P<0. 05). Also the total immobility time Significantly increase compared to the ovarectomized (0 mg/kg) group showed (P<0. 05, P<0. 01). Our findings showed that ovarectomized significantly increase Anxiety but this increase Anxiety not associated with depression. The administration of zinc chloride demonstrated effect of anxiolytic and depression. Thus, it seems that zinc chloride has different effects on the behavior of depression Ovariectomized peri-pubertaly and postpubertaly.

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APA: Copy

GHAHRAMANI, P., ESHAGH HAROONI, H., FATEMI TABATABAEI, S.R., & MOAZEDI, A.A.. (2018). Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(4 ), 0-0. SID. https://sid.ir/paper/367920/en

Vancouver: Copy

GHAHRAMANI P., ESHAGH HAROONI H., FATEMI TABATABAEI S.R., MOAZEDI A.A.. Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2018;30(4 ):0-0. Available from: https://sid.ir/paper/367920/en

IEEE: Copy

P. GHAHRAMANI, H. ESHAGH HAROONI, S.R. FATEMI TABATABAEI, and A.A. MOAZEDI, “Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 4 , pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/367920/en

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