DETERMINATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA POLYMORPHISM IN PATIENTS WITH HELICOBACTER PYLORI INFECTION

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GOUDARZI HOSSEIN; SEYEDJAVADI SIMA SADAT; GOUDARZI MEHDI

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Information Journal Paper

Title

DETERMINATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA POLYMORPHISM IN PATIENTS WITH HELICOBACTER PYLORI INFECTION

Author(s)

GOUDARZI HOSSEIN | SEYEDJAVADI SIMA SADAT | GOUDARZI MEHDI | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

PPARΓ GENE POLYMORPHISMQ2

GASTRIC CANCERQ2

Abstract

Introduction: Peroxisome proliferator-activated receptor gamma (PPARg) is a ligand-dependent transcription factor involved in various disease processes including inflammation and carcinogenesis. This study aimed to determine polymorphism of PPARg gene and its association with HELICOBACTER PYLORI infection and gastrointestinal diseases in patients.Materials and Methods: Two hundred patients with HELICOBACTER PYLORI infection were examined. H. pylori infection was diagnosed by histology, rapid urease test (RUT), culture, ELISA and PCR. PPARg polymorphism was analyzed by PCR-based restriction fragment length polymorphism.Results: In total 200 patients (4 GASTRIC CANCERs, 141 gastritis, 35 peptic ulcers, 18 duodenal ulcers, 2 peptic ulcer and duodenal ulcer) with HELICOBACTER PYLORI infection were enrolled. The frequency of PPARg G (Ala12) allele (5%) showed a significant association with GASTRIC CANCER (P=0.004) or gastritis (P=0.007).PPARg GC (Pro12Ala) allele (35%) showed a significant association with duodenal ulcer (P=0.03) or gastritis (P=0.002).Conclusion: Pro12Ala PPARg polymorphism is associated with GASTRIC CANCER and gastritis and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.Finally, our study suggests the potential association between PPARg polymorphism and H. pylori infection in the development of GASTRIC CANCER and peptic ulcer and gastritis.

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APA: Copy

GOUDARZI, HOSSEIN, SEYEDJAVADI, SIMA SADAT, & GOUDARZI, MEHDI. (2012). DETERMINATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA POLYMORPHISM IN PATIENTS WITH HELICOBACTER PYLORI INFECTION. KOOMESH, 13(2 (42)), 159-165. SID. https://sid.ir/paper/36920/en

Vancouver: Copy

GOUDARZI HOSSEIN, SEYEDJAVADI SIMA SADAT, GOUDARZI MEHDI. DETERMINATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA POLYMORPHISM IN PATIENTS WITH HELICOBACTER PYLORI INFECTION. KOOMESH[Internet]. 2012;13(2 (42)):159-165. Available from: https://sid.ir/paper/36920/en

IEEE: Copy

HOSSEIN GOUDARZI, SIMA SADAT SEYEDJAVADI, and MEHDI GOUDARZI, “DETERMINATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA POLYMORPHISM IN PATIENTS WITH HELICOBACTER PYLORI INFECTION,” KOOMESH, vol. 13, no. 2 (42), pp. 159–165, 2012, [Online]. Available: https://sid.ir/paper/36920/en

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