Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats

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SOHAILY SHAHRAM; EIZADI MOJTABA; Tarmast Daniel

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:21 | Issue:4 (72) Page(s): 53-59

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Title

Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats

Author(s)

SOHAILY SHAHRAM | EIZADI MOJTABA | Tarmast Daniel | Issue Writer Certificate

Keywords

Resistance trainingQ1

FOXO1 geneQ1

Fasting glucoseQ2

Type 2 diabetesQ2

Abstract

Background and Objective: Hormone and genetic disorders are the most important causes of hyperglycemia in obese and diabetes patients. This study was done to determine the effect of the Resistance training program on FOXO1 gene expression in subcutaneous adipose tissue as an effective transcription factor in insulin signaling pathways, Fasting glucose and insulin resistance in type 2 diabetic rats. Methods: In this experimental study, Type 2 diabetes induced by high fat diet and Streptozotocin (STZ, 30 mg/kg/bw) intraperitoneal injection in 14 male wistar rats (220± 20 g). Animals were randomly allocated into exercise (n=7) and control (n=7) groups. Exercise group were participated in Resistance training program (6 weeks, 5 days/weekly). Fasting blood glucose and insulin as well FOXO1 gene expression in subcutaneous adipose tissue were measured lasted exercise session in the two geoups. Results: Resistance training significantly reduces in Fasting glucose, insulin resistance and FOXO1 gene expression in subcutaneous adipose tissue in exercise group in compared to control group (P<0. 05). Conclusion: Resistance training lead to decrease of insulin resistance and blood glucose by inhibiting FOXO1 gene expression in subcutaneous adipose tissue in diabetic rats.

Cites

The Effect of 6 Week Resistance Training Program on Foxo1 Expression in Liver Cells and Glucose and Insulin Levels in Type 2 Diabetic Rats

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APA: Copy

SOHAILY, SHAHRAM, EIZADI, MOJTABA, & Tarmast, Daniel. (2020). Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(4 (72)), 53-59. SID. https://sid.ir/paper/369283/en

Vancouver: Copy

SOHAILY SHAHRAM, EIZADI MOJTABA, Tarmast Daniel. Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;21(4 (72)):53-59. Available from: https://sid.ir/paper/369283/en

IEEE: Copy

SHAHRAM SOHAILY, MOJTABA EIZADI, and Daniel Tarmast, “Effect of resistance training on FOXO1 gene expression in subcutaneous fatty tissue in diabetic wistar rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 4 (72), pp. 53–59, 2020, [Online]. Available: https://sid.ir/paper/369283/en

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