DOSE-DEPENDENT ANTINOCICEPTIVE RESPONSE OF MORPHINE MICROINJECTED INTO THE NUCLEUS CUNEIFORMIS ANDEFFECT OF IN ACTIVATION OF THIS AREA ON PAIN MODULATION IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAGHPARAST A.; SEPEHRI GH.R.; SHAFIEI M.N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2003 | Volume:4 | Issue:1-2 Page(s): 9-22

Download Full-Text

Persian Verion

View:

753

Download:

Cites:

Information Journal Paper

Title

DOSE-DEPENDENT ANTINOCICEPTIVE RESPONSE OF MORPHINE MICROINJECTED INTO THE NUCLEUS CUNEIFORMIS ANDEFFECT OF IN ACTIVATION OF THIS AREA ON PAIN MODULATION IN RAT

Author(s)

HAGHPARAST A. | SEPEHRI GH.R. | SHAFIEI M.N. | Issue Writer Certificate

Keywords

NUCLEUS CUNEIFORMISQ3

MORPHINEQ3

LIDOCAINEQ2

TAIL FLICK TESTQ3

PAIN MODULATIONQ3

RATQ2

Abstract

Introduction: The cuneiforms nucleus (CnF) is one of the reticular formation entities which rests in midbrain region. This nucleus controls pain indirectly through its binding wither astral ventromedial medulla (RVM). From previous researches, its been proved that thisnucleus has ultra structural similarities and bidirectional connections with periaqueductal gray(PAG) matter. In present study, in according to these similarities and connections, we tried toknow the antinociceptive response of MORPHINE microinjected into the NUCLEUS CUNEIFORMIS and effect of inactivation of this area on PAIN MODULATION.Materials and Methods. RATs were placed in stereotaxic instrument, with a hole being drilled over cerebellum on skull and a guide cannula was forced down just 1 mm above the CnF.Following surgery and recovery period, various doses of MORPHINE (10, 20 and 40 َg/0.5 َlsaline) and LIDOCAINE 5% (0.5 َl) were microinjected into the CnF. Tail Flick Latency (TFL) and Maximal Possible Effect (%MPE) were measured 30 min in 5-min intervals, before and after any injection as an index for nociceptive responses. Naloxone was injected intravenously to exactly pinpoint MORPHINE action as a non-selective antagonist.Results. MORPHINE increased TFL in a dose dependent manner. Also inactivation of CnF by LIDOCAINE increased TFL. Simultaneously microinjection of MORPHINE and LIDOCAINE increased TFL which was less than MORPHINE effect (%MPE) alone. While injecting MORPHINE intravenously with LIDOCAINE microinjection increased significantly TFL but these effects were reversed by naloxone administration.Conclusion. It is clear that CnF has opioid receptors, specially µreceptor, that follow in a dose dependent manner. On the other hand, we suggest that CnF inactivation with LIDOCAINEinhibits an inhibitory output that projects to RVM specially off-cells in this area and thisdisinhibition causes PAIN MODULATION.

Cites

EFFECTS OF MORPHINE AND LIDOCAINE ADMINISTRATION INTO THE CUNEIFORMIS NUCLEUS OF RATS ON ACUTE AND CHRONIC PAIN MODULATION BY FORMALIN TEST

References

No record.

Cite

APA: Copy

HAGHPARAST, A., SEPEHRI, GH.R., & SHAFIEI, M.N.. (2003). DOSE-DEPENDENT ANTINOCICEPTIVE RESPONSE OF MORPHINE MICROINJECTED INTO THE NUCLEUS CUNEIFORMIS ANDEFFECT OF IN ACTIVATION OF THIS AREA ON PAIN MODULATION IN RAT . KOOMESH, 4(1-2), 9-22. SID. https://sid.ir/paper/36980/en

Vancouver: Copy

HAGHPARAST A., SEPEHRI GH.R., SHAFIEI M.N.. DOSE-DEPENDENT ANTINOCICEPTIVE RESPONSE OF MORPHINE MICROINJECTED INTO THE NUCLEUS CUNEIFORMIS ANDEFFECT OF IN ACTIVATION OF THIS AREA ON PAIN MODULATION IN RAT . KOOMESH[Internet]. 2003;4(1-2):9-22. Available from: https://sid.ir/paper/36980/en

IEEE: Copy

A. HAGHPARAST, GH.R. SEPEHRI, and M.N. SHAFIEI, “DOSE-DEPENDENT ANTINOCICEPTIVE RESPONSE OF MORPHINE MICROINJECTED INTO THE NUCLEUS CUNEIFORMIS ANDEFFECT OF IN ACTIVATION OF THIS AREA ON PAIN MODULATION IN RAT ,” KOOMESH, vol. 4, no. 1-2, pp. 9–22, 2003, [Online]. Available: https://sid.ir/paper/36980/en

Related Journal Papers