Effect of Acesulfame k on Liver Enzymes and Liver Tissue in Immature Male Rats

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Parsapour Niloufar; NOORI ALI; Nazem Habiballa

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:30 | Issue:185 Page(s): 14-22

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Information Journal Paper

Title

Effect of Acesulfame k on Liver Enzymes and Liver Tissue in Immature Male Rats

Author(s)

Parsapour Niloufar | NOORI ALI | Nazem Habiballa | Issue Writer Certificate

Keywords

acesulfame kQ1

liver factorsQ1

liver tissueQ1

artificial sweetenerQ1

Abstract

Background and purpose: artificial sweeteners are increasingly used in food products, so, it is necessary to study the effects of these additives on liver. Materials and methods: In this experimental study, 30 immature male rats were divided into five groups (n=6 per group) and acesulfame k at 50, 100, 200, and 400 mg/kg were injected intraperitoneally to all groups for 30 days. One and 30 days after the last injection, blood samples were taken from the rats' eye, and the levels of FBS, HDL, LDL, AST, ALT, ALP, triglyceride, and cholesterol were measured. A number of rats were dissected in each group and their livers were removed to prepare tissue sections. The slides were examined by optical microscopy and data were analyzed applying ANOVA. Results: The study showed that acesulfame k for 30 days, at 200 and 400mg/kg caused a significant increase in glucose level (P<0. 05) and at 100, 200, and 400mg/kg significantly decreased LDL levels (P<0. 001). Also, tissue disorders such as congestion, sinusoid abnormalities, and hepatocytes lysis were observed in liver samples in a dose-dependent manner. However, no significant changes were seen in other factors. Conclusion: It seems that acesulfame k even at doses greater than 50 mg/kg for 30 days does not cause serious toxicity to immature male rats, due to the lack of changes in most liver factors, and liver tissue disorders may be restored over time.

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APA: Copy

Parsapour, Niloufar, NOORI, ALI, & Nazem, Habiballa. (2020). Effect of Acesulfame k on Liver Enzymes and Liver Tissue in Immature Male Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(185 ), 14-22. SID. https://sid.ir/paper/370356/en

Vancouver: Copy

Parsapour Niloufar, NOORI ALI, Nazem Habiballa. Effect of Acesulfame k on Liver Enzymes and Liver Tissue in Immature Male Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(185 ):14-22. Available from: https://sid.ir/paper/370356/en

IEEE: Copy

Niloufar Parsapour, ALI NOORI, and Habiballa Nazem, “Effect of Acesulfame k on Liver Enzymes and Liver Tissue in Immature Male Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 185 , pp. 14–22, 2020, [Online]. Available: https://sid.ir/paper/370356/en

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