ROLE OF 5HT1A RECEPTOR ON POTENTIATION OF FIELD POTENTIALS IN DENTATE GYRUS OF PENTYLENETETRAZOL -KINDLED RATS

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KIANI NEJAD ATEFEH; VAEZI GHOLAMHASSAN; AZHDARI ZARMEHRI HASSAN; MOHAMMAD ZADEH MOHAMMAD

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Journal: Koomesh Year:2017 | Volume:19 | Issue:3 (67) Page(s): 641-647

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Title

ROLE OF 5HT1A RECEPTOR ON POTENTIATION OF FIELD POTENTIALS IN DENTATE GYRUS OF PENTYLENETETRAZOL -KINDLED RATS

Author(s)

KIANI NEJAD ATEFEH | VAEZI GHOLAMHASSAN | AZHDARI ZARMEHRI HASSAN | MOHAMMAD ZADEH MOHAMMAD | Issue Writer Certificate

Keywords

EPILEPSYQ2

KINDLINGQ2

SEROTONIN 5HT1A RECEPTOR ANTAGONISTQ1

ELECTRIC STIMULATIONQ3

RATSQ2

Abstract

Introduction: There are many evidence to indicate the role of serotoninergic system and serotoninergic activation in seizure attacks. Given the role of serotonin 5-HT1A receptors in synaptic activity and seizure models, and, the similarity of the mechanisms involved in causing seizures and long term potentiation (LTP), the purpose of this study was to investigate the role of this receptor in pentylenetetrazol (PTZ) -induced synaptic strengthening.Materials and Methods: 24 Male Wistar RATS (n=20, 220-320 g) were divided into 6 groups; Group1 (control); without any interference after surgery stereotoxic placement of stimulation electrode, Local Field Potential (LFP) was recorded for 20min.Then; the LTP was induced with tetanic stimulation. Group2: All experimental procedures were similar to the group 1, the difference was that the one-month period before the surgery, the animals kindled with PTZ injection. Groups 3-5: All experimental procedures were similar to the group 2, the difference was that the serotonin receptor antagonist (WAY-100635; at a concentration 12.5, 25 and 50nM) was injected intraventricularly. Group 6 received WAY-100635 only.Results: The results showed that groups 1 and 2 were different responded from one another after LTP induction of LTP with tetanic pulse (p<0.001). Field Excitatory Post-synaptic Potential (fEPSP) and Population Spike (PS) decreased significantly in groups of 3-5 compared to group 2 (p<0.001). Also, administration of WAY-100635 reduce fEPSP and PS.Conclusion: The results showed that 5HT1A receptor antagonist attenuated the induction of LTP in kindled animals. It seems that serotonin agonist that enhances LTP induction and thus may be useful in enhancing learning and memory in people with EPILEPSY.

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References

KINDLING-INDUCED CHANGES IN PLASTICITY OF THE RAT AMYGDALA AND HIPPOCAMPUS

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APA: Copy

KIANI NEJAD, ATEFEH, VAEZI, GHOLAMHASSAN, AZHDARI ZARMEHRI, HASSAN, & MOHAMMAD ZADEH, MOHAMMAD. (2017). ROLE OF 5HT1A RECEPTOR ON POTENTIATION OF FIELD POTENTIALS IN DENTATE GYRUS OF PENTYLENETETRAZOL -KINDLED RATS. KOOMESH, 19(3 (67)), 641-647. SID. https://sid.ir/paper/37064/en

Vancouver: Copy

KIANI NEJAD ATEFEH, VAEZI GHOLAMHASSAN, AZHDARI ZARMEHRI HASSAN, MOHAMMAD ZADEH MOHAMMAD. ROLE OF 5HT1A RECEPTOR ON POTENTIATION OF FIELD POTENTIALS IN DENTATE GYRUS OF PENTYLENETETRAZOL -KINDLED RATS. KOOMESH[Internet]. 2017;19(3 (67)):641-647. Available from: https://sid.ir/paper/37064/en

IEEE: Copy

ATEFEH KIANI NEJAD, GHOLAMHASSAN VAEZI, HASSAN AZHDARI ZARMEHRI, and MOHAMMAD MOHAMMAD ZADEH, “ROLE OF 5HT1A RECEPTOR ON POTENTIATION OF FIELD POTENTIALS IN DENTATE GYRUS OF PENTYLENETETRAZOL -KINDLED RATS,” KOOMESH, vol. 19, no. 3 (67), pp. 641–647, 2017, [Online]. Available: https://sid.ir/paper/37064/en

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