PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF MAJOR DEPRESSION DISORDER VIA PROTEOMIC APPROACH FROM CEREBROSPINAL FLUID SAMPLE

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REZAEI TAVIRANI MAJID; VAFAEI REZA; MANSOURI VAHID; ZAMANIAN AZODI MONA

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Journal: Koomesh Year:2017 | Volume:19 | Issue:3 (67) Page(s): 577-583

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Title

PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF MAJOR DEPRESSION DISORDER VIA PROTEOMIC APPROACH FROM CEREBROSPINAL FLUID SAMPLE

Author(s)

REZAEI TAVIRANI MAJID | VAFAEI REZA | MANSOURI VAHID | ZAMANIAN AZODI MONA | Issue Writer Certificate

Keywords

MAJOR DEPRESSION DISORDERQ2

PROTEIN INTERACTION MAPSQ1

PROTEIN COMPLEXQ1

GENE ONTOLOGYQ1

Abstract

Introduction: As the MAJOR DEPRESSION DISORDER (MDD) is one of the prevalent psychiatric conditions, molecular characteristic is important to gain a better understanding of its complex nature. In this study, the protein-protein interaction network analysis is carried out in order to have a better understanding the molecular mechanism of MDD.Materials and Methods: The MDD differentially expressed proteins of cerebral fluid were extracted from the literature. Cytoscape Software was used for the network construction of 39 retrieved proteins. In addition, Cytoscape plug-ins, MCODE and ClueGO+CluePedia identified the PROTEIN COMPLEXes and biological processes, respectively.Results: The MDD map centrality analysis identified 15 hub proteins. This network comprises of four PROTEIN COMPLEXes and seven significant biological processes.Conclusion: In this study, some of the central proteins, PROTEIN COMPLEXes, and biological processes related to MDD are introduced. The further investigations can help validating possible drug targets and diagnostic biomarkers.

Cites

Evaluation of Protein Complexes in Muscular Atrophy Using Interaction Map Analysis

References

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APA: Copy

REZAEI TAVIRANI, MAJID, VAFAEI, REZA, MANSOURI, VAHID, & ZAMANIAN AZODI, MONA. (2017). PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF MAJOR DEPRESSION DISORDER VIA PROTEOMIC APPROACH FROM CEREBROSPINAL FLUID SAMPLE. KOOMESH, 19(3 (67)), 577-583. SID. https://sid.ir/paper/37073/en

Vancouver: Copy

REZAEI TAVIRANI MAJID, VAFAEI REZA, MANSOURI VAHID, ZAMANIAN AZODI MONA. PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF MAJOR DEPRESSION DISORDER VIA PROTEOMIC APPROACH FROM CEREBROSPINAL FLUID SAMPLE. KOOMESH[Internet]. 2017;19(3 (67)):577-583. Available from: https://sid.ir/paper/37073/en

IEEE: Copy

MAJID REZAEI TAVIRANI, REZA VAFAEI, VAHID MANSOURI, and MONA ZAMANIAN AZODI, “PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF MAJOR DEPRESSION DISORDER VIA PROTEOMIC APPROACH FROM CEREBROSPINAL FLUID SAMPLE,” KOOMESH, vol. 19, no. 3 (67), pp. 577–583, 2017, [Online]. Available: https://sid.ir/paper/37073/en

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