Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study

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TAMADDONI AHMAD; Alijanpour Morteza

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:30 | Issue:185 Page(s): 51-60

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Title

Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study

Author(s)

TAMADDONI AHMAD | Alijanpour Morteza | Issue Writer Certificate

Keywords

major thalassemiaQ3

endocrine glandsQ3

short statureQ3

recombinant growth hormoneQ1

Abstract

Background and purpose: Beta thalassemia major is one of the most common inherited blood diseases and patients with this condition require regular blood transfusions. The resulting iron overload deposition causes endocrine gland disorders, including growth hormone (GH) abnormality. In this study, we examined the effects of recombinant growth hormone (rGH) in these patients. Materials and methods: This retrospective study was performed in thalassemia major patients in Amirkola Thalassemia Center, using the medical records (2011-2018), to evaluate the therapeutic effects of rGH on growth velocity of six short stature patients aged 7-15 years (four boys and two girls). On the basis of abnormal or normal response to GH provocation test, the patients were included in GH deficiency (GHD) group (n=3) and idiopathic short stature (ISS) group (n=3), respectively. The data were analyzed in SPSS-18. Results: The mean age of patients was 11. 00 ± 2. 75 years old. The mean values for growth velocity before and after the treatment were 4. 00± 0. 86 and 7. 83 ± 1. 25 cm/year in GHD group (P=0. 057) and 4. 06 ± 0. 81 and 6. 00 ± 1. 50 cm/year in ISS group, respectively (P=0. 023). Conclusion: In this study, the positive therapeutic effects of rGh in improvement of growth velocity were seen in thalassemia major patients (both GHD and ISS groups).

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APA: Copy

TAMADDONI, AHMAD, & Alijanpour, Morteza. (2020). Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(185 ), 51-60. SID. https://sid.ir/paper/371051/en

Vancouver: Copy

TAMADDONI AHMAD, Alijanpour Morteza. Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(185 ):51-60. Available from: https://sid.ir/paper/371051/en

IEEE: Copy

AHMAD TAMADDONI, and Morteza Alijanpour, “Therapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 185 , pp. 51–60, 2020, [Online]. Available: https://sid.ir/paper/371051/en

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