POSSIBLE ROLE OF OPIOIDERGIC SYSTEM IN SEROTONIN INDUCED ANALGESIA IN THE FORMALIN TEST

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MAHJAL NAEBI A.R.; AHMADIANI A.A.H.

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Journal: PHARMACEUTICAL SCIENCES Year:2000 | Volume:- | Issue:3 Page(s): 79-83

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Title

POSSIBLE ROLE OF OPIOIDERGIC SYSTEM IN SEROTONIN INDUCED ANALGESIA IN THE FORMALIN TEST

Author(s)

MAHJAL NAEBI A.R. | AHMADIANI A.A.H. | Issue Writer Certificate

Keywords

SEROTONINQ3

FENFLURAMINEQ3

OPIOIDERGIC SYSTEMQ3

NALOXONEQ3

FORMALIN TESTQ3

Abstract

There is much evidence indicating that the serotonergic system involves in the central regulation of nociceptive sensitivity. However, the exact mechanism of serotonergic system and also its interaction with other neural systems has not yet been understood. In this study, the effect of SEROTONIN (5-HT) and FENFLURAMINE, as a SEROTONIN releaser, on formalin induced pain and also its possible interaction with OPIOIDERGIC SYSTEM have been studied. Results obtained from this study show that SEROTONIN in intrathecal (100 mg/rat, i.t.) and intracerebroventricular (100 mg/rat, i.c.v.) administration produces significant (P < 0.05) analgesia in early and late phase offormalin test. These analgesic effects were abolished by pretreatment with the NALOXONE hydrochloride (2 mg/kg, Lp.). Furthennore, FENFLURAMINE (10 mg/kg, i.p.) induced analgesia in both phases which has been reversed by pretreatment with the NALOXONE (2 mg/kg, i.p.). The results of our study may indicate that SEROTONIN induces antinociceptive effect in chronic inflammatory pain through activation of opioidergic neurons, but it needs more investigation in order to clarify the mechanism of this interaction.

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APA: Copy

MAHJAL NAEBI, A.R., & AHMADIANI, A.A.H.. (2000). POSSIBLE ROLE OF OPIOIDERGIC SYSTEM IN SEROTONIN INDUCED ANALGESIA IN THE FORMALIN TEST. PHARMACEUTICAL SCIENCES, -(3), 79-83. SID. https://sid.ir/paper/372083/en

Vancouver: Copy

MAHJAL NAEBI A.R., AHMADIANI A.A.H.. POSSIBLE ROLE OF OPIOIDERGIC SYSTEM IN SEROTONIN INDUCED ANALGESIA IN THE FORMALIN TEST. PHARMACEUTICAL SCIENCES[Internet]. 2000;-(3):79-83. Available from: https://sid.ir/paper/372083/en

IEEE: Copy

A.R. MAHJAL NAEBI, and A.A.H. AHMADIANI, “POSSIBLE ROLE OF OPIOIDERGIC SYSTEM IN SEROTONIN INDUCED ANALGESIA IN THE FORMALIN TEST,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 79–83, 2000, [Online]. Available: https://sid.ir/paper/372083/en

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