The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice with Breast Cancer

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SHAHVALI KOOHSHOORI Y.; MARANDI M.; KARGARFARD M.; VASEGHI G.; MOSHTAGHIAN J.

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Journal: Iranian Journal of Breast Diseases Year:2021 | Volume:13 | Issue:4 (51) Page(s): 68-76

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Title

The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice with Breast Cancer

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Primordial PreventionQ1

Primary PreventionQ1

Secondary PreventionQ1

ApoptosisQ1

Aerobic ExerciseQ1

DetrainingQ1

Abstract

Introduction: The aim of this study was to investigate the effect of Aerobic Exercise with Detraining in different phases of prevention on Bcl-2 gene expression and protein. Methods: For this purpose, 32 female BALB-c mice (18-20 g) were purchased and randomly assigned to four groups of Primordial Prevention (A), Primary Prevention (B), Secondary Prevention (C), and control (D). Group A performed Aerobic Exercise for 4 weeks, followed by injection of 4T1 cells and 8 weeks of Detraining after the injection. Group B performed Aerobic Exercise for 4 weeks immediately after the injection of 4T1 cells and then detrained for 4 weeks. Group C received a 4T1 cell injection and maintained a sedentary life for 4 weeks, followed by 4 weeks of Aerobic Exercise. The subjects were killed 48 hours after the last training session and Detraining courses and tumor tissues were removed. Real-time polymerase chain reaction was used to measure gene expression and western blotting was used to measure protein content. The one-way ANOVA test was used to analyze the data. Results: The mean gene expression due to Aerobic Exercise was significantly (P<0. 001) lower in groups A (0. 481), B (0. 323), and C (0. 035) compared with group D (1. 711). Also, Aerobic Exercise caused a significant decrease in Bcl-2 (P=0. 005) protein expression in groups A (0. 692), B (0. 821), and C (0. 670) compared with group D (1. 000). It should be noted that tumor growth in experimental groups was not significantly different from the control group (P=0. 092). Conclusion: Exercise may be able to reduce anti-apoptotic agents in tumor cells, leading to Apoptosis of tumor cells and reduced tumor growth.

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APA: Copy

SHAHVALI KOOHSHOORI, Y., MARANDI, M., KARGARFARD, M., VASEGHI, G., & MOSHTAGHIAN, J.. (2021). The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice with Breast Cancer. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 13(4 (51) ), 68-76. SID. https://sid.ir/paper/372121/en

Vancouver: Copy

SHAHVALI KOOHSHOORI Y., MARANDI M., KARGARFARD M., VASEGHI G., MOSHTAGHIAN J.. The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice with Breast Cancer. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2021;13(4 (51) ):68-76. Available from: https://sid.ir/paper/372121/en

IEEE: Copy

Y. SHAHVALI KOOHSHOORI, M. MARANDI, M. KARGARFARD, G. VASEGHI, and J. MOSHTAGHIAN, “The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice with Breast Cancer,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 13, no. 4 (51) , pp. 68–76, 2021, [Online]. Available: https://sid.ir/paper/372121/en

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