Changes of Tumor Necrosis Factor-Alpha Gene Expression in Hippocampus of Rats after Brain Stroke and Endurance Training

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AHMADI R.; Taheri Kalani A.H.

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Journal: Journal of Advanced Biomedical Sciences Year:2020 | Volume:10 | Issue:1 Page(s): 2012-2019

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Title

Changes of Tumor Necrosis Factor-Alpha Gene Expression in Hippocampus of Rats after Brain Stroke and Endurance Training

Author(s)

AHMADI R. | Taheri Kalani A.H. | Issue Writer Certificate

Keywords

InflammationQ2

TNF-aQ1

hippocampusQ2

strokeQ2

endurance trainingQ1

Abstract

Background & Objective: Inflammation has a dominant role in the pathogenesis of neurological diseases, and pro-inflammatory factors such as tumor necrosis factor-α (TNF-α ), fuel inflammatory reactions in brain tissue. This study was conducted to determine the effect of 8-week endurance training on TNF-α gene expression in the hippocampus of rats after brain stroke. Materials & Methods: Twenty one adult male Wistar rats (weighing 210-252 gr) were purchased and randomly divided into three groups: control, stroke and stroke+ training groups. stroke was induced by the occlusion of both common carotid arteries (CCA) for 45 min. The rats in the training group were run on a treadmill with a speed of 18 to 30 meters per minute for 20 to 50 minutes per session, 5 days a week for 8 weeks. Forty-eight hours after the last training session, rats were sacrificed and gene expression of TNF-α in the hippocampus was measured with Real Time-PCR technique. Results: Results showed that endurance training resulted in a significant decrease in gene expression of TNF-α in the hippocampus of rats (p=0. 0001). Also, in comparison with the control group, stroke led to a significant increase in gene expression of TNF-α in the hippocampus of the stroke group (p=0. 0001). Conclusion: In general, 8 weeks of endurance training can strongly affect pro-inflammatory factors associated with stroke via decreasing TNF-α . Therefore, it is recommended that endurance training be used as a non-pharmacological treatment for the prevention of neurological complications associated with stroke.

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References

EFFECT OF INTENSIVE EXERCISE TRAINING AND VITAMIN E SUPPLEMENTATION ON THE CONTENT OF RAT BRAIN-DRIVED NEUROTROPHIC FACTORS

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APA: Copy

AHMADI, R., & Taheri Kalani, A.H.. (2020). Changes of Tumor Necrosis Factor-Alpha Gene Expression in Hippocampus of Rats after Brain Stroke and Endurance Training. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(1 ), 2012-2019. SID. https://sid.ir/paper/372334/en

Vancouver: Copy

AHMADI R., Taheri Kalani A.H.. Changes of Tumor Necrosis Factor-Alpha Gene Expression in Hippocampus of Rats after Brain Stroke and Endurance Training. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;10(1 ):2012-2019. Available from: https://sid.ir/paper/372334/en

IEEE: Copy

R. AHMADI, and A.H. Taheri Kalani, “Changes of Tumor Necrosis Factor-Alpha Gene Expression in Hippocampus of Rats after Brain Stroke and Endurance Training,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 1 , pp. 2012–2019, 2020, [Online]. Available: https://sid.ir/paper/372334/en

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