ROLE OF INCREASING SERUM TUMOR NECROSIS FACTOR ON HYPERALGESIA AND EDEMA VARIATION DURING DIFFERENT STAGES OF ADJUVANT- INDUCED ARTHRITIS IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKHTARI ZEINAB; ZARINGHALAM JALAL; EIDI AKRAM; HAERI RUHANI ALI; TEKIEH ELAHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2013 | Volume:14 | Issue:3 (47) Page(s): 357-366

Download Full-Text

Persian Verion

View:

792

Download:

Cites:

Information Journal Paper

Title

ROLE OF INCREASING SERUM TUMOR NECROSIS FACTOR ON HYPERALGESIA AND EDEMA VARIATION DURING DIFFERENT STAGES OF ADJUVANT- INDUCED ARTHRITIS IN MALE RATS

Author(s)

Keywords

HYPERALGESIAQ2

EDEMAQ2

TUMOR NECROSIS FACTOR-ALPHAQ2

RECEPTORSQ2

OPIOIDQ3

MUQ3

Abstract

Introduction: Tumor necrosis factor a (TNF-a) is a potent cytokine that exerts pleiotropic functions in inflammatory symptoms. With regarding to the important role of TNFa in HYPERALGESIA and EDEMA induction via intra-cellular signaling pathways, we aimed to investigate the role of increasing serum TNF-a on HYPERALGESIA and EDEMA and spinal MU OPIOID receptor (mOR) expression variation during different stages of Complete Freound Adjuvant- induced arthritis in male rats.Materials and Methods: Mono-arthritis was induced by CFA and then inflammatory symptoms (HYPERALGESIA and EDEMA) were assessed on day 0, 3,7th, 14 and 21 following CFAinduction. In addition, anti-TNF-a was daily administered for 21 days for all different experimental groups. Spinal mOR expression were detected by western blotting.Results: Our results showed that anti-TNFa administration in AA group resulted in decrease of paw volume and HYPERALGESIA until day 14, whereas, those symptoms were increased on day 21 following CFAinduction. Our study stated that anti- TNFa antibody administration causes a significant decreasing in spinal mOR protein expression on days 14 and 21 of the study.Conclusion: This study confirmed the time-dependent and bi-directional effects of serum TNF-a levsel on CFA-induced HYPERALGESIA, which it can say, a portion of these effects might be mediated via spinal mOR expression variation.

Cites

No record.

References

No record.

Cite

APA: Copy

AKHTARI, ZEINAB, ZARINGHALAM, JALAL, EIDI, AKRAM, HAERI RUHANI, ALI, & TEKIEH, ELAHEH. (2013). ROLE OF INCREASING SERUM TUMOR NECROSIS FACTOR ON HYPERALGESIA AND EDEMA VARIATION DURING DIFFERENT STAGES OF ADJUVANT- INDUCED ARTHRITIS IN MALE RATS. KOOMESH, 14(3 (47)), 357-366. SID. https://sid.ir/paper/37240/en

Vancouver: Copy

AKHTARI ZEINAB, ZARINGHALAM JALAL, EIDI AKRAM, HAERI RUHANI ALI, TEKIEH ELAHEH. ROLE OF INCREASING SERUM TUMOR NECROSIS FACTOR ON HYPERALGESIA AND EDEMA VARIATION DURING DIFFERENT STAGES OF ADJUVANT- INDUCED ARTHRITIS IN MALE RATS. KOOMESH[Internet]. 2013;14(3 (47)):357-366. Available from: https://sid.ir/paper/37240/en

IEEE: Copy

ZEINAB AKHTARI, JALAL ZARINGHALAM, AKRAM EIDI, ALI HAERI RUHANI, and ELAHEH TEKIEH, “ROLE OF INCREASING SERUM TUMOR NECROSIS FACTOR ON HYPERALGESIA AND EDEMA VARIATION DURING DIFFERENT STAGES OF ADJUVANT- INDUCED ARTHRITIS IN MALE RATS,” KOOMESH, vol. 14, no. 3 (47), pp. 357–366, 2013, [Online]. Available: https://sid.ir/paper/37240/en

Related Journal Papers