THE EFFECT OF LONG-TERM ORAL ADMINISTRATION OF NIGELLA. SATIVUM ON THE CONTRACTILE REACTIVITY OF THORACIC AORTA IN DIABETIC RATS

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ROGHANI MEHRDAD; BALUCHNEJADMOJARAD TOURANDOKHT; VAEZ MAHDAVI M.R.; VASEEI M.

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Journal: Koomesh Year:2006 | Volume:7 | Issue:3-4 (20) Page(s): 153-157

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Title

THE EFFECT OF LONG-TERM ORAL ADMINISTRATION OF NIGELLA. SATIVUM ON THE CONTRACTILE REACTIVITY OF THORACIC AORTA IN DIABETIC RATS

Author(s)

ROGHANI MEHRDAD | BALUCHNEJADMOJARAD TOURANDOKHT | VAEZ MAHDAVI M.R. | VASEEI M. | Issue Writer Certificate

Keywords

NIGELLA SATIVUMQ2

VASCULAR SYSTEMQ3

DIABETES MELLITUSQ3

CONTRACTILE RESPONSEQ3

RATQ3

Abstract

Introduction: Therapeutics, especially medical plants with minimum side-effects are of high value in preventing vascular complications of DIABETES MELLITUS in long term. Considering the evidences about the anti-diabetic effects of Nigella. Sativum (NS), the current study was conducted to evaluate the effect of oral two-month administration of NS on the contractile reactivity of isolated aorta in male diabetic RATs.Material & Methods: Male Wistar RATs (n=32) were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered. The treatment groups were received oral administration of NS-mixed pelleted food (6.25%) for two months. After two months, the contractile reactivity of aortic rings to KCl and noreadrenaline was determined using isolated tissue setup.Results: CONTRACTILE RESPONSE to cumulative KCl and noreadrenaline followed a dose-dependent pattern in aortic rings in all groups. In addition, the maximum contractile reactivity was significantly higher in the diabetic group compared to the control one (p<0.0001).Meanwhile, this response was lower in NS-treated diabetic group in comparison with untreated diabetic group (p<0.05).Conclusion: Long-term oral administration of Nigella. sativum attenuated the enhanced vascular responsiveness in DIABETES MELLITUS and some developed cardiovascular complications due to diabetes.

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APA: Copy

ROGHANI, MEHRDAD, BALUCHNEJADMOJARAD, TOURANDOKHT, VAEZ MAHDAVI, M.R., & VASEEI, M.. (2006). THE EFFECT OF LONG-TERM ORAL ADMINISTRATION OF NIGELLA. SATIVUM ON THE CONTRACTILE REACTIVITY OF THORACIC AORTA IN DIABETIC RATS. KOOMESH, 7(3-4 (20)), 153-157. SID. https://sid.ir/paper/37278/en

Vancouver: Copy

ROGHANI MEHRDAD, BALUCHNEJADMOJARAD TOURANDOKHT, VAEZ MAHDAVI M.R., VASEEI M.. THE EFFECT OF LONG-TERM ORAL ADMINISTRATION OF NIGELLA. SATIVUM ON THE CONTRACTILE REACTIVITY OF THORACIC AORTA IN DIABETIC RATS. KOOMESH[Internet]. 2006;7(3-4 (20)):153-157. Available from: https://sid.ir/paper/37278/en

IEEE: Copy

MEHRDAD ROGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, M.R. VAEZ MAHDAVI, and M. VASEEI, “THE EFFECT OF LONG-TERM ORAL ADMINISTRATION OF NIGELLA. SATIVUM ON THE CONTRACTILE REACTIVITY OF THORACIC AORTA IN DIABETIC RATS,” KOOMESH, vol. 7, no. 3-4 (20), pp. 153–157, 2006, [Online]. Available: https://sid.ir/paper/37278/en

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