THE EFFECTS OF CIMETIDINE ON MOTOR ACTIVITY: AN EVALUATION THE ROLE OF OPIOID RECEPTORS

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MILADI GORJI H.; RASHIDIPOUR A.; FOROUZESHFARD M.; TAHERIAN ABAS ALI; VAFAEI ABAS ALI; SADEGHI HASAN

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Journal: Koomesh Year:2006 | Volume:7 | Issue:3-4 (20) Page(s): 119-123

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Title

THE EFFECTS OF CIMETIDINE ON MOTOR ACTIVITY: AN EVALUATION THE ROLE OF OPIOID RECEPTORS

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Keywords

MOTOR ACTIVITYQ2

CIMETIDINEQ4

MORPHINEQ3

OPIOID RECEPTORQ4

HISTAMINIC RECEPTORQ3

NALOXANEQ2

Abstract

Introduction: Effects of CIMETIDINE (CIM) on locomotor is controversial. This study was designed to evaluate the effects of CIM on MOTOR ACTIVITY and possible roles of OPIOID RECEPTORs in CIM-induced decrement in locoMOTOR ACTIVITY in mice.Materials & Methods: Thirty-six male mice (25-30gr) were divided into six groups in this study. LocoMOTOR ACTIVITY was evaluated using an automated activity monitor system. CIM (50 mg\kg, i.p.) was injected 25 min before testing in presence or absence naloxone (2 mg/kg, sc). MORPHINE (5 mg/kg, i.p) was injected 25 min before testing in the presence or absence CIM. Decreased MOTOR ACTIVITY significantly. Pretreatment of or MORPHINE did not change CIM - induced response significantly.Results: The results showed that CIM significantly decreased MOTOR ACTIVITY in mice (P=0.000). Pretreatment of nalxone did not change CIM-induced response significantly. MORPHINE alone did not change MOTOR ACTIVITY. Pretreatment of ClM did not change MORPHINE-induced response.Conclusion: Data indicated that CIMETIDINE can reduce MOTOR ACTIVITY independence from interaction with OPIOID RECEPTORs.

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APA: Copy

MILADI GORJI, H., RASHIDIPOUR, A., FOROUZESHFARD, M., TAHERIAN, ABAS ALI, VAFAEI, ABAS ALI, & SADEGHI, HASAN. (2006). THE EFFECTS OF CIMETIDINE ON MOTOR ACTIVITY: AN EVALUATION THE ROLE OF OPIOID RECEPTORS. KOOMESH, 7(3-4 (20)), 119-123. SID. https://sid.ir/paper/37290/en

Vancouver: Copy

MILADI GORJI H., RASHIDIPOUR A., FOROUZESHFARD M., TAHERIAN ABAS ALI, VAFAEI ABAS ALI, SADEGHI HASAN. THE EFFECTS OF CIMETIDINE ON MOTOR ACTIVITY: AN EVALUATION THE ROLE OF OPIOID RECEPTORS. KOOMESH[Internet]. 2006;7(3-4 (20)):119-123. Available from: https://sid.ir/paper/37290/en

IEEE: Copy

H. MILADI GORJI, A. RASHIDIPOUR, M. FOROUZESHFARD, ABAS ALI TAHERIAN, ABAS ALI VAFAEI, and HASAN SADEGHI, “THE EFFECTS OF CIMETIDINE ON MOTOR ACTIVITY: AN EVALUATION THE ROLE OF OPIOID RECEPTORS,” KOOMESH, vol. 7, no. 3-4 (20), pp. 119–123, 2006, [Online]. Available: https://sid.ir/paper/37290/en

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