Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Khovarnagh N.; SEYEDALIPOUR B.; TARAVATI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:10 | Issue:1 Page(s): 2081-2093

Download Full-Text

Persian Verion

View:

365

Download:

Cites:

Information Journal Paper

Title

Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum

Author(s)

Khovarnagh N. | SEYEDALIPOUR B. | TARAVATI A. | Issue Writer Certificate

Keywords

AcetamipridQ1

N-acetyl cysteineQ1

S-methyl cysteineQ1

RatQ1

Antioxidant enzymesQ1

Abstract

Background & Objectives: Acetamiprid (ACP), as a neonicotinoid toxin, causes free radicals production and oxidative stress in various organisms. The aim of this study was to evaluate the antioxidative effects of N-acetylcysteine (NAC) and S-methylcysteine (SMC) on reducing acetaminoprid-induced oxidative stress in serum and kidney of Rats. Materials & Methods: In this experimental study, 42 male Wistar Rats were randomly divided into 6 groups of 7 including one control, one sham (normal saline) and five experimental groups, which intra-peritoneally received ACP (5 mg/kg), NAG (160 mg/kg), SMC (100 mg/kg), ACP+NAC, ACP+SMC, and ACP+ NAC+SMC for one week. After sepaRation of serum and kidney tissue, the activity of the catalase (CAT), glutathione S-transferase (GST), glutathione concentRation (GSH), malondialdehyde (MDA) and total antioxidant (TAC) was determined. Results: Acetamiprid caused significant increase in GST activity in serum and kidney (p< 0. 01), CAT activity in serum and kidney (p< 0. 05) but insignificant increase in MDA level and insignificant decrease in GSH and TAC compared to control. NAC and SMC, alone and in combination with ACP, restored the levels of TAC, GSH and MDA and activities of CAT and GST. Conclusion: Acetamiprid increases lipid peroxidation, activity of CAT and GST, and decreases the concentRation of GSH and TAC, presumably by producing free radicals. AdministRation of NAC and SMS as antioxidants causes a decrease in Acetamiprid toxicity due to relative reduction of free radicals.

Cites

No record.

References

Cite

APA: Copy

Khovarnagh, N., SEYEDALIPOUR, B., & TARAVATI, A.. (2020). Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(1 ), 2081-2093. SID. https://sid.ir/paper/373496/en

Vancouver: Copy

Khovarnagh N., SEYEDALIPOUR B., TARAVATI A.. Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;10(1 ):2081-2093. Available from: https://sid.ir/paper/373496/en

IEEE: Copy

N. Khovarnagh, B. SEYEDALIPOUR, and A. TARAVATI, “Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 1 , pp. 2081–2093, 2020, [Online]. Available: https://sid.ir/paper/373496/en

Related Journal Papers