A STEREOLOGICAL STUDY OF THE EFFECT OF LOCALLY ADMINISTERED GROWTH HORMONE ON THE MICROSTRUCTURE OF THE TIBIAL GROWTH PLATE IN IMMATURE RABBITS

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MASHAYEKHI Y.; REED M.; SIBBONS P.; HOWARD C.V.

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Journal: Feyz Medical Sciences Journal Year:2003 | Volume:6 | Issue:23 Page(s): 0-0

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Title

A STEREOLOGICAL STUDY OF THE EFFECT OF LOCALLY ADMINISTERED GROWTH HORMONE ON THE MICROSTRUCTURE OF THE TIBIAL GROWTH PLATE IN IMMATURE RABBITS

Author(s)

MASHAYEKHI Y. | REED M. | SIBBONS P. | HOWARD C.V. | Issue Writer Certificate

Keywords

CONGENITAL ANOMALYQ2

CONSANGUINEOUS MARRIAGEQ4

FIRST COUSIN MARRIAGEQ4

SECOND COUSIN MARRIAGEQ4

NON CONSANGUINEOUS MARRIAGE.Q4

Abstract

History and objectives: The mechanism of growth hormone (GH) effects on growth plate (GP)and its chondrocytes is very important, so, in this study the microstructural of proximal tibial GP of rabbits were investigated with designed-based stereological methods by conventional light and confocal epifluorescence microscopy. Material and Methods: The tissue came from a study into longitudinalgrowth using minipomps surgically implanted into the right upper tibial GP of 9 weeks old rabbits, administering GH at 10 and 100 µg/day for a period of 21 days. Saline only administered and non operated groups served as controls. The following stereological parameters were unbiasedly estimated: GP volume and height; chondrocyte volume, surface and number densities. These direct measurements lead to estimates of chondrocyte total volume, surfaceand number; mean chondrocyte volume and surface in the number-weighted distribution. Right and left effects were compared using the paired sample t-Test. Dosage versus control were compared by initially performing single factor ANOVA, then if there was any significant difference, Dunnett,s multiple comparison test was performed. Results: No significant differences were found between the right and left tibial and salhne and control groups in the total quantities. The GP volume and height and chondrocyte total volume showed no significant differences between the treatment and control groups. Conclusions: The main conclusions were that the GH acts on rabbit proximal tibial GP by inducing chondrocyte hyperplasia but not hypertrophy . At the administered doses of GH, namely 10 and 100 µg/day, the predominant effects were mediated systemically. The operative procedure of implanting a minipomp had no detectable effect on any of the parameters measured. GH had an effect on the local cytostructure of the GP on the treated side. At the administered doses of GH no convincing overall does response was demonstrated. 1) Shahrod Faculty of Medical Sciences, Shahrood, IRAN. 2) Dept. of Pathology, Liverpool University, UK. Consanguineous marriage is one of the most important etiology of morbidity and anomaly in neonates and children and annualy thousands neonate and child sacrify due to consonguineous marriage. This study was performed shabihkhani hospital in Kashan. Material and Methods: All the neonates who were borned in hospital (shabihkhani) in this descriptive study were determined then these questions were ordered (sex, gestational age, type of delivery, perinatal care, drug history, special disease in mother, type of anomaly, history of still birth or anomaly in previous pregnancy). Type of anomaly in first 24 hours was distinguished for further classification paraclinic tests and consultations were used. Results: In this study from the total of 3529 neonate in one year, 768 (21/8%) were from CONSANGUINEOUS MARRIAGE and 2761 (78.2%) from nonconsanguineous marriage of them total pregnancies 109 (3.08%) had anomaly and 7.03% from consanguineous and 2% from nonconsanguineous and from all of the anomaly in CONSANGUINEOUS MARRIAGE 72.3% had in first. Cousin marriage and 27.7% had in SECOND COUSIN MARRIAGE. Conclusion: Percentage of CONSANGUINEOUS MARRIAGE in our study was prominet and rate of anomaly in neonates of CONSANGUINEOUS MARRIAGE obviously was more than expected and in situations with relative marriage happened rate of anomaly clearly increased more and in these marriage major anomaly were predominant.

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محاسبه چگالی حجمی و سطحی

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APA: Copy

MASHAYEKHI, Y., REED, M., SIBBONS, P., & HOWARD, C.V.. (2003). A STEREOLOGICAL STUDY OF THE EFFECT OF LOCALLY ADMINISTERED GROWTH HORMONE ON THE MICROSTRUCTURE OF THE TIBIAL GROWTH PLATE IN IMMATURE RABBITS. FEYZ, 6(23), 0-0. SID. https://sid.ir/paper/373864/en

Vancouver: Copy

MASHAYEKHI Y., REED M., SIBBONS P., HOWARD C.V.. A STEREOLOGICAL STUDY OF THE EFFECT OF LOCALLY ADMINISTERED GROWTH HORMONE ON THE MICROSTRUCTURE OF THE TIBIAL GROWTH PLATE IN IMMATURE RABBITS. FEYZ[Internet]. 2003;6(23):0-0. Available from: https://sid.ir/paper/373864/en

IEEE: Copy

Y. MASHAYEKHI, M. REED, P. SIBBONS, and C.V. HOWARD, “A STEREOLOGICAL STUDY OF THE EFFECT OF LOCALLY ADMINISTERED GROWTH HORMONE ON THE MICROSTRUCTURE OF THE TIBIAL GROWTH PLATE IN IMMATURE RABBITS,” FEYZ, vol. 6, no. 23, pp. 0–0, 2003, [Online]. Available: https://sid.ir/paper/373864/en

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