POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES

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SOUFIABADI M.; SADEGHIPOUR H.R.; SHAABANZADEH A.R.; ZARINDAST M.R.; DEHPOUR A.R.

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Journal: Koomesh Year:2001 | Volume:2 | Issue:3-4 Page(s): 177-184

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Title

POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES

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Keywords

ANXIETYQ4

PLUS-MAZEQ4

NITRIC OXIDEQ2

ESTRADIOL BENZOATQ2

PROGESTERONEQ2

Abstract

Introduction. NITRIC OXIDE (NO) is a neuromodulator and an intercellular messenger that mediate several functions in the CNS. Possible involvement of NO in ANXIETY like behavior induced by ovarian hormones was studied in ovarectomized female rats.Materials and Methods.12 groups of rats were ovarectomized bilateraly and 14 days after surgery they received ESTRADIOL BENZOATe (10µg/kg, sc) and or PROGESTERONE (25 mg/kg, sc) or corn oil (0.2 ml/rat, sc) and L-Name (60 mg/kg, i.p) or L-Aarginine (100 mg/kg, i.p) or normal saline (0.5 ml/rat, i.p). The behavioral tests began 6 hours after PROGESTERONE and 3 hours after estradiol administeration. Behavioural test consisted measurment of exploratory activities on elevated plus maze test.Results. There was increased exploration of open arms under PROGESTERONE administeration alone or with L-Name, and decreased under estradiol administeration alone or with L-Arginine. The anxiolytic-like effect of PROGESTERONE abolished when L-Arginine administerated, and anxiogenic-like effect of estradiol was inhibited when L-Name injected.Conclusion. These data indicate involvement of NO in the mediation of the effects of ovarian steroid hormones on ANXIETY process.

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APA: Copy

SOUFIABADI, M., SADEGHIPOUR, H.R., SHAABANZADEH, A.R., ZARINDAST, M.R., & DEHPOUR, A.R.. (2001). POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES. KOOMESH, 2(3-4), 177-184. SID. https://sid.ir/paper/37429/en

Vancouver: Copy

SOUFIABADI M., SADEGHIPOUR H.R., SHAABANZADEH A.R., ZARINDAST M.R., DEHPOUR A.R.. POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES. KOOMESH[Internet]. 2001;2(3-4):177-184. Available from: https://sid.ir/paper/37429/en

IEEE: Copy

M. SOUFIABADI, H.R. SADEGHIPOUR, A.R. SHAABANZADEH, M.R. ZARINDAST, and A.R. DEHPOUR, “POSSIBLE INVOLVEMENT OF NITRIC OXIDE (NO) IN ANXIETY-LIKE BEHAVIOR INDUCED BY FEMALE STEROID HORMONES,” KOOMESH, vol. 2, no. 3-4, pp. 177–184, 2001, [Online]. Available: https://sid.ir/paper/37429/en

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