The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats

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PARSAEIFAR AHMAD; DABIDI ROSHAN VALIOLLAH

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Journal: JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT Year:2019 | Volume:6 | Issue:12 Page(s): 59-69

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Title

The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats

Author(s)

PARSAEIFAR AHMAD | DABIDI ROSHAN VALIOLLAH | Issue Writer Certificate

Keywords

DoxorubicinQ1

AgingQ1

Voluntary physical activityQ1

Abstract

Background and Aim: Despite numerous studies on Doxorubicin-induced cardiac toxicity, there are a limited of domestic studies into its effect on skeletal muscle. The present study aimed to evaluate the effect of cumulative Doxorubicin doses on the Voluntary physical activity distance in Aging active rat models. Materials and Methods: Twenty-four male Wistar rats (12 weeks old) were divided into three groups including saline (S), Doxorubicin (D), and Doxorubicin plus Voluntary physical activity (DWR). Aging model was induced through injection of 100 mg / kg D-galactose solved in normal saline for 9 weeks. Voluntary physical activity was performed on a wheel running during the last 6 weeks of Aging induction. The distance traveled by the subjects was recorded on a daily basis. In the last 15 days, 1 mg / kg / day Doxorubicin or saline (cumulative dose of 15 mg) was intraperitoneally injected to the Doxorubicin and saline receiving rats. Data were analyzed through variance analysis with repeated measures and one-way ANOVA and the LSD post hoc tests. Results: Doxorubicin resulted in an insignificant reduction in the physical activity distance in the rats of DWR group (p<0. 21). In addition, Doxorubicin led to a significant reduction in the weight of the rats in groups D (p<0. 003) and DWR (p<0. 001) on the final day as compared to the eighth week. Moreover, a significant decrease in the weight of rats was observed in groups D (p<0. 001) and DWR (p<0. 002) as compared to group S on the final day. Conclusion: Doxorubicin has a significant relationship with weight losing and also reduction of distance of Voluntary physical activity.

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APA: Copy

PARSAEIFAR, AHMAD, & DABIDI ROSHAN, VALIOLLAH. (2019). The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, 6(12 ), 59-69. SID. https://sid.ir/paper/374409/en

Vancouver: Copy

PARSAEIFAR AHMAD, DABIDI ROSHAN VALIOLLAH. The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT[Internet]. 2019;6(12 ):59-69. Available from: https://sid.ir/paper/374409/en

IEEE: Copy

AHMAD PARSAEIFAR, and VALIOLLAH DABIDI ROSHAN, “The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats,” JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, vol. 6, no. 12 , pp. 59–69, 2019, [Online]. Available: https://sid.ir/paper/374409/en

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