Association of polymorphisms of FASN gene with productive and reproductive traits in Iranian Holstein cows of Kerman province

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Rezakhani nejad Hagar; DASHAB GHOLAM REZA; Vafa Valleh Mehdi

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Journal: Animal Science Journal Year:2019 | Volume:31 | Issue:121 Page(s): 253-262

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Information Journal Paper

Title

Association of polymorphisms of FASN gene with productive and reproductive traits in Iranian Holstein cows of Kerman province

Author(s)

Rezakhani nejad Hagar | DASHAB GHOLAM REZA | Vafa Valleh Mehdi | Issue Writer Certificate

Keywords

FASN geneQ1

SequencingQ1

PolymorphismQ2

Holstein cattleQ2

Abstract

Fatty acid synthase (FASN), a multifunctional protein that carries out the synthesis of fatty acids, is coded by FASN gene which is known as major candied gene and plays a central role in de novo lipogenesis in mammals. This study was conducted to detect single nucleotide Polymorphisms (SNPs) of the FASN gene and explore their relationships with three economically important traits including milk production (M), calving interval (CI) and conception rate (CR) in Holstein cows of Kerman province. The whole blood samples corresponding to the 38 Holstein cows with high and low estimate breeding values were collected. Genomic DNA was extracted from blood samples of the cows using a genomic DNA kit according to the manufacturer’ s instructions. The genetic material was used for polymerase chain reaction amplification of selected gene fragments (750bp length from exon 37 to 39). All of PCR products were subsequently used directly for Sequencing. Analysis of the target sequence followed by multiple regression of average allele substitution effects on M, CI, and CR traits revealed 58 SNP markers, among which 8 SNPs were totally associated with productive and reproductive traits. (M), (CI) and (CR) were affected by three (g. 16593A>G, g. 16670C>A and g. 16776C>T), three (g. 16524G, C, T>A, g. 16830G, C, T>A, g. 16833A, T>G) and two (g. 16594A, C>G and g. 16811A, T>G) SNPs respectively (P<0. 05). Association between Polymorphism in FASN gene and traits could be used as molecular markers for determination of animal's genetic potential as well as breeding strategies in Holstein population.

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APA: Copy

Rezakhani nejad, Hagar, DASHAB, GHOLAM REZA, & Vafa Valleh, Mehdi. (2019). Association of polymorphisms of FASN gene with productive and reproductive traits in Iranian Holstein cows of Kerman province. ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI), 31(121 ), 253-262. SID. https://sid.ir/paper/375385/en

Vancouver: Copy

Rezakhani nejad Hagar, DASHAB GHOLAM REZA, Vafa Valleh Mehdi. Association of polymorphisms of FASN gene with productive and reproductive traits in Iranian Holstein cows of Kerman province. ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI)[Internet]. 2019;31(121 ):253-262. Available from: https://sid.ir/paper/375385/en

IEEE: Copy

Hagar Rezakhani nejad, GHOLAM REZA DASHAB, and Mehdi Vafa Valleh, “Association of polymorphisms of FASN gene with productive and reproductive traits in Iranian Holstein cows of Kerman province,” ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI), vol. 31, no. 121 , pp. 253–262, 2019, [Online]. Available: https://sid.ir/paper/375385/en

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